New signals from the invasive front (Q36488744)

14 August 2017

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title

New signals from the invasive front (English)

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14 August 2017

Gerhard Christofori

1

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PubMed ID

16724056

14 August 2017

language of work or name

English

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publication date

1 May 2006

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14 August 2017

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14 August 2017

441

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14 August 2017

444-450

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14 August 2017

7092

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https://scigraph.springernature.com/pub.10.1038/nature04872

14 August 2017

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cites work

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.

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https://api.crossref.org/works/10.1038%2FNATURE04872

Epithelial-mesenchymal transitions in tumour progression

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Molecular requirements for epithelial-mesenchymal transition during tumor progression

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Scatter-factor and semaphorin receptors: cell signalling for invasive growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Cancer therapy: can the challenge be MET?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Met, metastasis, motility and more

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Interplay between scatter factor receptors and B plexins controls invasive growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

The semaphorin 4D receptor controls invasive growth by coupling with Met

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Negative feedback regulation of Met-dependent invasive growth by Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Targeting the tumor and its microenvironment by a dual-function decoy Met receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis

21 January 2018

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Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

21 January 2018

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In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

21 January 2018

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Memo mediates ErbB2-driven cell motility.

21 January 2018

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Hepatocyte growth factor enhances CXCR4 expression favoring breast cancer cell invasiveness.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypox

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

A causal role for E-cadherin in the transition from adenoma to carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Unraveling signalling cascades for the Snail family of transcription factors

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Epithelial-mesenchymal transitions: twist in development and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Epigenetic versus genetic alterations in the inactivation of E-cadherin

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE04872

Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Role of integrins in cell invasion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Integrins: bidirectional, allosteric signaling machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Integrin signalling during tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Tumour-educated macrophages promote tumour progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Cytokines in cancer pathogenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Tumorigenesis and the angiogenic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Role of angiogenesis in tumor growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Focus on lymphangiogenesis in tumor metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

A multigenic program mediating breast cancer metastasis to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Genes that mediate breast cancer metastasis to lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Metadherin, a cell surface protein in breast tumors that mediates lung metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Dissemination and growth of cancer cells in metastatic sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

CD44 is required for two consecutive steps in HGF/c-Met signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

The MET oncogene drives a genetic programme linking cancer to haemostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

Wnt-dependent regulation of the E-cadherin repressor snail

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

7 January 2021

N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

7 January 2021

Therapeutic targeting of the tumor microenvironment

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

7 January 2021

A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04872

7 January 2021

Identifiers

DOI

10.1038/NATURE04872

1 reference

14 August 2017

1 reference

PubMed ID

16724056