Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis (Q44043137)

29 November 2017

Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis (English)

1 reference

29 November 2017

Theresa Lopez

1

1 reference

PubMed ID

12086849

29 November 2017

Douglas Hanahan

series ordinal

2

1 reference

29 November 2017

1 May 2002

1 reference

29 November 2017

1 reference

29 November 2017

1

1 reference

29 November 2017

339-353

1 reference

29 November 2017

4

1 reference

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons.

29 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Integrins and E-cadherin cooperate with IGF-I to induce migration of epithelial colonic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Type-2 IGF receptor: a multi-ligand binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Parental imprinting of the mouse insulin-like growth factor II gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

A matter of life and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Embryological and molecular investigations of parental imprinting on mouse chromosome 7.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Met receptor tyrosine kinase: enhanced signaling through adapter proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Expression of IGF system genes during T-antigen driven pituitary tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

The role of insulin-like growth factor I and its receptor in cell growth, transformation, apoptosis, and chemoresistance in solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Tumor cells utilize multiple pathways to down-modulate apoptosis. Lessons from a mouse model of islet cell carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Insulin-like growth factors and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Insulin-like growth factor II is focally up-regulated and functionally involved as a second signal for oncogene-induced tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

A causal role for E-cadherin in the transition from adenoma to carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Insulin-like growth factor expression in human cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

The IGF axis and hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

The role of the insulin-like growth factor system in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Insulin-Like Growth Factor-I (IGF-I) Attenuation of Growth Hormone Is Enhanced by Overexpression of Pituitary IGF-I Receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

Association of insulin receptor substrate 1 with simian virus 40 large T antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900055-7

7 January 2021

10.1016/S1535-6108(02)00055-7

Identifiers

DOI

1 reference

29 November 2017

1 reference

PubMed ID

12086849