Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation (Q36494927)

14 August 2017

Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation (English)

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14 August 2017

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1 reference

Michelle L Manni

1

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14 August 2017

Sivanarayana Mandalapu

2

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14 August 2017

Kevin J McHugh

3

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14 August 2017

M Merle Elloso

4

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14 August 2017

Paul L Dudas

5

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14 August 2017

John F Alcorn

6

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14 August 2017

language of work or name

English

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publication date

4 January 2016

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14 August 2017

Journal of Immunology

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14 August 2017

196

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14 August 2017

3

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14 August 2017

963-977

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TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

14 August 2017

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Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma

30 September 2017

1 reference

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The complex relationship between inflammation and lung function in severe asthma

30 September 2017

1 reference

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Muc5b is required for airway defence

30 September 2017

1 reference

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Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma

30 September 2017

1 reference

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Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung

30 September 2017

1 reference

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STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production

30 September 2017

1 reference

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IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia

30 September 2017

1 reference

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A global perspective in asthma: from phenotype to endotype

30 September 2017

1 reference

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Severe asthma: from characteristics to phenotypes to endotypes

30 September 2017

1 reference

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IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner

30 September 2017

1 reference

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Lebrikizumab treatment in adults with asthma

30 September 2017

1 reference

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Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice

30 September 2017

1 reference

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T(H)17 cells in asthma and inflammation

30 September 2017

1 reference

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STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease

30 September 2017

1 reference

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IL-17 and IL-22 in atopic allergic disease

30 September 2017

1 reference

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Structure and signalling in the IL-17 receptor family

30 September 2017

1 reference

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Mucus hypersecretion in asthma: causes and effects

30 September 2017

1 reference

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TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice

30 September 2017

1 reference

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Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma

30 September 2017

1 reference

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Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Increased sputum and bronchial biopsy IL-13 expression in severe asthma

30 September 2017

1 reference

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Targeting TNF-alpha: a novel therapeutic approach for asthma

30 September 2017

1 reference

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Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements

30 September 2017

1 reference

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Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation

30 September 2017

1 reference

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Signaling pathways in Th2 development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Measuring lung function in mice: the phenotyping uncertainty principle

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis.

28 June 2018

1 reference

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Input impedance and peripheral inhomogeneity of dog lungs

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Dupilumab in persistent asthma

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Dupilumab in persistent asthma with elevated eosinophil levels

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4724491

Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects

21 September 2018

1 reference

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Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation

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12 December 2020

Association of IL4R gene polymorphisms with asthma in Chinese populations

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Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies

1 reference

12 December 2020

Increased serum IL-17 is an independent risk factor for severe asthma

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Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects

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12 December 2020

STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation

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12 December 2020

Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: a randomized trial

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A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1501531

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

26729801

1 reference