Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance (Q36504175)

14 August 2017

Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance (English)

1 reference

14 August 2017

0 references

antibiotic resistance

1 reference

1 reference

1

Katarzyna Walkiewicz

1 reference

14 August 2017

Andres S Benitez Cardenas

2

1 reference

14 August 2017

Christine Sun

3

1 reference

14 August 2017

Colin Bacorn

4

1 reference

14 August 2017

Gerda Saxer

5

1 reference

14 August 2017

Yousif Shamoo

6

1 reference

14 August 2017

language of work or name

English

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publication date

10 December 2012

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Proceedings of the National Academy of Sciences of the United States of America

14 August 2017

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14 August 2017

109

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14 August 2017

52

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14 August 2017

21408-21413

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FREQ-Seq: a rapid, cost-effective, sequencing-based method to determine allele frequencies directly from mixed populations

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Diminishing returns epistasis among beneficial mutations decelerates adaptation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Crystal structure of Bacteroides thetaiotaomicron TetX2: A tetracycline degrading monooxygenase at 2.8 Å resolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Genetic variation and the fate of beneficial mutations in asexual populations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

The repeatability of adaptive radiation during long-term experimental evolution of Escherichia coli in a multiple nutrient environment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Mutational effects and the evolution of new protein functions.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Exploring protein fitness landscapes by directed evolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Mechanistic approaches to the study of evolution: the functional synthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Microbial genetics: Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

The SOS response regulates adaptive mutation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Evolution of high mutation rates in experimental populations of E. coli

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Metabolic flux and fitness

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. 1963.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

The molecular diversity of adaptive convergence.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Negative epistasis between beneficial mutations in an evolving bacterial population

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

In vivo molecular evolution reveals biophysical origins of organismal fitness

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

ANALYZING TABLES OF STATISTICAL TESTS

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23236139

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1209335110

1 reference

release_ltzsvjxwy5fu7cq63atiq62xza

14 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ltzsvjxwy5fu7cq63atiq62xza

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

14 August 2017

1 reference