Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes. (Q36508312)

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scientific article published on 28 November 2012

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English	Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes.	scientific article published on 28 November 2012

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18 February 2020

Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes (English)

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Juliana Chung-ngor Chan

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Y Zhou

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D R Laybutt

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J Luzuriaga

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G Xu

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28 November 2012

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Creative Commons Attribution-NonCommercial 2.5 Generic

28 November 2012

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0 references

https://scigraph.springernature.com/pub.10.1007/s00125-012-2776-x

0 references

Obesity may attenuate the HbA1c-lowering effect of sitagliptin in Japanese type 2 diabetic patients

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30 September 2017

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.

1 reference

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30 September 2017

Exendin-4 improves blood glucose control in both young and aging normal non-diabetic mice, possible contribution of beta cell independent effects

1 reference

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30 September 2017

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice

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30 September 2017

Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

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30 September 2017

Common genetic variation in GLP1R and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects: a pilot study

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30 September 2017

Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?

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30 September 2017

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

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30 September 2017

Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice

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30 September 2017

Incretin-based therapies for type 2 diabetes mellitus

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30 September 2017

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

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30 September 2017

The incretin system and its role in type 2 diabetes mellitus

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30 September 2017

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

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30 September 2017

Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes Mellitus

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30 September 2017

Biology of incretins: GLP-1 and GIP

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30 September 2017

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

1 reference

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30 September 2017

Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

1 reference

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30 September 2017

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells

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30 September 2017

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

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30 September 2017

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21 September 2018

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

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30 September 2017

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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30 September 2017

A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells

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30 September 2017

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

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30 September 2017

The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice

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30 September 2017

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

1 reference

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30 September 2017

Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).

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30 September 2017

Fatty acids, lipotoxicity and insulin secretion

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30 September 2017

A role for glucagon-like peptide-1 in the central regulation of feeding

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30 September 2017

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

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30 September 2017

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

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30 September 2017

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

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30 September 2017

Stimulation of insulin secretion by long-chain free fatty acids. A direct pancreatic effect

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30 September 2017

The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

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30 September 2017

Glucose-dependent insulinotropic peptide impairs insulin signaling via inducing adipocyte inflammation in glucose-dependent insulinotropic peptide receptor-overexpressing adipocytes

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28 June 2018

The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects

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28 June 2018

Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice

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28 June 2018

Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity.

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21 September 2018

Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis

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21 September 2018

Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes

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21 September 2018

Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

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21 September 2018

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets

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21 September 2018

Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients

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21 September 2018

Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice

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21 September 2018

Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.

1 reference

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21 September 2018

Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes

1 reference

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21 September 2018

Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers

1 reference

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21 September 2018

A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM.

1 reference

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21 September 2018

Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2776-X

21 January 2018

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/23188390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type

1 reference

https://pubmed.ncbi.nlm.nih.gov/23188390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23188390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced incretin effect in type 2 (non-insulin-dependent) diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23188390

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-012-2776-X

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18 February 2020

1 reference

Europe PubMed Central

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18 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23188390%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

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