Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes (Q40176269)

18 September 2017

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes (English)

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18 September 2017

endoplasmic reticulum

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6

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D R Laybutt

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A M Preston

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M C Akerfeldt

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J G Kench

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A K Busch

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T J Biden

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18 September 2017

1 February 2007

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50

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752-763

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4

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https://scigraph.springernature.com/pub.10.1007/s00125-006-0590-z

18 September 2017

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cites work

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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12 December 2020

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

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12 December 2020

Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2.

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12 December 2020

A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.

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12 December 2020

Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function

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12 December 2020

Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans.

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12 December 2020

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

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12 December 2020

Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats

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12 December 2020

The mammalian unfolded protein response

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12 December 2020

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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12 December 2020

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

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12 December 2020

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

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12 December 2020

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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12 December 2020

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

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12 December 2020

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

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12 December 2020

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

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12 December 2020

Roles of CHOP/GADD153 in endoplasmic reticulum stress

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12 December 2020

Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure

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12 December 2020

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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12 December 2020

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

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12 December 2020

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

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12 December 2020

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

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12 December 2020

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

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12 December 2020

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

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12 December 2020

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

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12 December 2020

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

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12 December 2020

Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes

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12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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12 December 2020

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

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12 December 2020

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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12 December 2020

A time-dependent phase shift in the mammalian unfolded protein response

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12 December 2020

Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress

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12 December 2020

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

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12 December 2020

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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12 December 2020

Checkpoints of dueling dimers foil death wishes

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12 December 2020

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

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12 December 2020

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

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12 December 2020

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

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12 December 2020

Type 2 diabetes-a matter of beta-cell life and death?

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12 December 2020

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

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12 December 2020

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

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12 December 2020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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12 December 2020

Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

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12 December 2020

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

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12 December 2020

Endoplasmic reticulum stress and the development of diabetes: a review

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12 December 2020

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

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12 December 2020

Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium

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12 December 2020

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

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12 December 2020

10.1007/S00125-006-0590-Z

Identifiers

DOI

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18 September 2017

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