Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer (Q36509342)

14 August 2017

Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer (English)

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14 August 2017

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Jordi Camps

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14 August 2017

Jason J Pitt

2

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14 August 2017

Georg Emons

3

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14 August 2017

Amanda B Hummon

4

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14 August 2017

Chanelle M Case

5

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14 August 2017

Marian Grade

6

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14 August 2017

Tamara L Jones

7

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14 August 2017

Quang T Nguyen

8

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14 August 2017

B Michael Ghadimi

9

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14 August 2017

Tim Beissbarth

10

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14 August 2017

Michael J Difilippantonio

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14 August 2017

Natasha J Caplen

12

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14 August 2017

Thomas Ried

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14 August 2017

language of work or name

English

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publication date

14 January 2013

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14 August 2017

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14 August 2017

73

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14 August 2017

6

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14 August 2017

2003-2013

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describes a project that uses

14 August 2017

limma

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22 June 2022

https://europepmc.org/article/PMC/4729305

inferred from PubMed Central ID database lookup

cites work

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Comprehensive molecular characterization of human colon and rectal cancer

30 September 2017

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Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis

30 September 2017

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The consequences of chromosomal aneuploidy on the transcriptome of cancer cells

30 September 2017

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Notch: architect, landscaper, and guardian of the intestine

30 September 2017

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Making sense of cancer genomic data

30 September 2017

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SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma

30 September 2017

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A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.

30 September 2017

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Fibroblast growth factor receptor 3-IIIc mediates colorectal cancer growth and migration.

30 September 2017

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The landscape of somatic copy-number alteration across human cancers

30 September 2017

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Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling

30 September 2017

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SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

30 September 2017

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Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer

30 September 2017

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The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells

30 September 2017

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Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer

30 September 2017

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Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

30 September 2017

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Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

30 September 2017

1 reference

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

30 September 2017

1 reference

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Wnt signalling and its impact on development and cancer

30 September 2017

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Chromosomal breakpoints in primary colon cancer cluster at sites of structural variants in the genome

30 September 2017

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Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis

30 September 2017

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FGF18 in colorectal tumour cells: autocrine and paracrine effects

30 September 2017

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Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas

30 September 2017

1 reference

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Specificity, selection and significance of gene amplifications in cancer

30 September 2017

1 reference

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Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

30 September 2017

1 reference

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Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells

30 September 2017

1 reference

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affy--analysis of Affymetrix GeneChip data at the probe level

30 September 2017

1 reference

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Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex

30 September 2017

1 reference

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Chromosome aberrations in solid tumors

30 September 2017

1 reference

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Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

30 September 2017

1 reference

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Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

The Lnx family proteins function as molecular scaffolds for Numb family proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation

30 September 2017

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A genetic model for colorectal tumorigenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

Candidate driver genes in focal chromosomal aberrations of stage II colon cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

Homage to Theodor Boveri (1862-1915): Boveri's theory of cancer as a disease of the chromosomes, and the landscape of genomic imbalances in human carcinomas

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

Transcriptome profile of human colorectal adenomas.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

Genome-wide discovery of transcriptional modules from DNA sequence and gene expression.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729305

Notch signals control the fate of immature progenitor cells in the intestine

21 September 2018

1 reference

12 December 2020

Relationship of gene expression and chromosomal abnormalities in colorectal cancer

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12 December 2020

Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model

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12 December 2020

Klf5 is involved in self-renewal of mouse embryonic stem cells

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12 December 2020

10.1158/0008-5472.CAN-12-3159

Identifiers

DOI

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14 August 2017

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14 August 2017

PubMed publication ID

23319804

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