Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex (Q36517153)

14 August 2017

Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex (English)

1 reference

14 August 2017

Ivan Rivalta

3

0 references

author name string

Clarisse G Ricci

1

1 reference

14 August 2017

Rodrigo L Silveira

2

1 reference

14 August 2017

Victor S Batista

4

1 reference

14 August 2017

Munir S Skaf

5

1 reference

14 August 2017

language of work or name

English

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publication date

29 January 2016

1 reference

14 August 2017

1 reference

14 August 2017

6

1 reference

14 August 2017

19940

1 reference

Creative Commons Attribution 4.0 International

14 August 2017

start time

29 January 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Genome editing. The new frontier of genome engineering with CRISPR-Cas9

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

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The ensemble nature of allostery

30 September 2017

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Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA

30 September 2017

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Molecular mechanism of peroxisome proliferator-activated receptor α activation by WY14643: a new mode of ligand recognition and receptor stabilization

30 September 2017

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PPARγ signaling and metabolism: the good, the bad and the future

30 September 2017

1 reference

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Multidomain integration in the structure of the HNF-4α nuclear receptor complex

30 September 2017

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Solution Structures of PPARγ2/RXRα Complexes

30 September 2017

1 reference

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Exploring residue component contributions to dynamical network models of allostery

30 September 2017

1 reference

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Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

30 September 2017

1 reference

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Protein frustratometer: a tool to localize energetic frustration in protein molecules.

30 September 2017

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Allosteric pathways in imidazole glycerol phosphate synthase

30 September 2017

1 reference

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Mode of peroxisome proliferator-activated receptor γ activation by luteolin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Allostery and the Monod-Wyman-Changeux model after 50 years

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

On the role of frustration in the energy landscapes of allosteric proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Molecular mechanism of allosteric communication in the human PPARalpha-RXRalpha heterodimer

30 September 2017

1 reference

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Conformational analysis of nucleic acids revisited: Curves+

30 September 2017

1 reference

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INT131: a selective modulator of PPAR gamma

30 September 2017

1 reference

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DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

30 September 2017

1 reference

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Dynamical networks in tRNA:protein complexes

30 September 2017

1 reference

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

30 September 2017

1 reference

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Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

30 September 2017

1 reference

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Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids

30 September 2017

1 reference

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T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Localizing frustration in native proteins and protein assemblies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Partial agonists activate PPARgamma using a helix 12 independent mechanism

30 September 2017

1 reference

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Convergent algorithms for protein structural alignment

30 September 2017

1 reference

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Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

30 September 2017

1 reference

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A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

The many faces of PPARgamma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Scalable molecular dynamics with NAMD

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Principles for modulation of the nuclear receptor superfamily

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Estimating mutual information

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Finding and evaluating community structure in networks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Binding of ligands and activation of transcription by nuclear receptors.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

The PPARs: from orphan receptors to drug discovery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Peroxisome proliferator-activated receptors: nuclear control of metabolism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Nuclear receptor coregulators: cellular and molecular biology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimers: intermolecular synergy requires only the PPARgamma hormone-dependent activation function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

VMD: visual molecular dynamics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

The RXR heterodimers and orphan receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

The Energy Landscapes and Motions of Proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Solution NMR and computational methods for understanding protein allostery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Backbone dynamics of the glucocorticoid receptor DNA-binding domain

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Allosteric communication pathways and thermal rectification in PDZ-2 protein: a computational study.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Nuclear receptor full-length architectures: confronting myth and illusion with high resolution.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Dynamic correlation networks in human peroxisome proliferator-activated receptor-γ nuclear receptor protein

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

A simple clustering algorithm can be accurate enough for use in calculations of pKs in macromolecules

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Allosteric effects of DNA on transcriptional regulators

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731802

Comparison of simple potential functions for simulating liquid water

21 September 2018

1 reference

Algorithm 97: Shortest path

21 January 2018

1 reference

GROMACS 3.0: a package for molecular simulation and trajectory analysis

21 January 2018

1 reference

A comparison of15N NMR relaxation measurements with a molecular dynamics simulation: Backbone dynamics of the glucocorticoid receptor DNA-binding domain

21 January 2018

1 reference

Generalized correlation for biomolecular dynamics

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26823026

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ligand-escape pathways from the ligand-binding domain of PPARgamma receptor as probed by molecular dynamics simulations

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26823026

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP19940

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

26823026

1 reference