Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human condition (Q36521097)

14 August 2017

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title

Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human condition (English)

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14 August 2017

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1

William T Cefalu

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PubMed ID

16804194

14 August 2017

language of work or name

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1 January 2006

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14 August 2017

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14 August 2017

47

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14 August 2017

3

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14 August 2017

186-198

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Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

14 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

The NOD mouse: a model of immune dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Alteration of Islet Cell Populations in Spontaneously Diabetic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Serum leptin levels as a marker for a syndrome X-like condition in wild baboons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Swine models of type 2 diabetes mellitus: insulin resistance, glucose tolerance, and cardiovascular complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Islet amyloid polypeptide (IAPP):cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Pancreatic beta-cell loss and preservation in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Pleiotropic effects of genes for insulin resistance on adiposity in baboons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Genomic structure of the human OB receptor and identification of two novel intronic microsatellites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

PPARs and the complex journey to obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Effects of weight gain and loss on metabolic rate, glucose tolerance, and serum lipids in domestic cats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Diabetes-induced accelerated atherosclerosis in swine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

The insulin resistance syndrome revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Heterogeneity of insulin responses: phases leading to type 2 (non-insulin-dependent) diabetes mellitus in the rhesus monkey.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Feline models of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Economic costs of diabetes in the US in 2002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Islet amyloid and type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Spontaneous pancreatic islet amyloidosis in 40 baboons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Islet amyloid, islet-amyloid polypeptide, and diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of european prospective investigation of cancer and nutrition (EPIC-Norfolk)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Use of the Göttingen minipig as a model of diabetes, with special focus on type 1 diabetes research

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Development of the multiple metabolic syndrome: an epidemiologic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

beta-Cell death during progression to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Molecular approaches to study control of glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Islet amyloid polypeptide: a review of its biology and potential roles in the pathogenesis of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

High dose intravenous glucose tolerance test and serum insulin and glucagon levels in diabetic and non-diabetic cats: relationships to insular amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Early oxidative stress in the diabetic kidney: effect of DL-alpha-lipoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Leptin receptor missense mutation in the fatty Zucker rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Cellular mechanism of nutritionally induced insulin resistance: the desert rodent Psammomys obesus and other animals in which insulin resistance leads to detrimental outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Nutritionally induced diabetes in desert rodents as models of type 2 diabetes: Acomys cahirinus (spiny mice) and Psammomys obesus (desert gerbil).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Obesity as the core of the metabolic syndrome and the management of coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Naturally occurring and experimental diabetes in cynomolgus monkeys: a comparison of carbohydrate and lipid metabolism and islet pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Old world nonhuman primate models of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

Global and societal implications of the diabetes epidemic

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.47.3.186

21 January 2018

Identifiers

DOI

10.1093/ILAR.47.3.186

1 reference

14 August 2017

1 reference

PubMed ID

16804194