Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-Induced Expression of RANKL. (Q36521118)

14 August 2017

Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-Induced Expression of RANKL. (English)

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14 August 2017

M Onal

1

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14 August 2017

H C St John

2

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14 August 2017

A L Danielson

3

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14 August 2017

J W Markert

4

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14 August 2017

E M Riley

5

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14 August 2017

J W Pike

6

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14 August 2017

language of work or name

English

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publication date

8 December 2015

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14 August 2017

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14 August 2017

157

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2

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14 August 2017

482-496

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Deletion of the Distal Tnfsf11 RL-D2 Enhancer That Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice

14 August 2017

1 reference

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The selection and function of cell type-specific enhancers

30 September 2017

1 reference

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Lymphocytes in atherosclerosis

30 September 2017

1 reference

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A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse

30 September 2017

1 reference

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T cell-expressed CD40L potentiates the bone anabolic activity of intermittent PTH treatment

30 September 2017

1 reference

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Transcriptional regulation of the human TNFSF11 gene in T cells via a cell type-selective set of distal enhancers

30 September 2017

1 reference

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T-cells and B-cells in osteoporosis

30 September 2017

1 reference

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Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency

30 September 2017

1 reference

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The immune system, bone and RANKL.

30 September 2017

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Osteocyte RANKL: new insights into the control of bone remodeling

30 September 2017

1 reference

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The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice

30 September 2017

1 reference

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Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo

30 September 2017

1 reference

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Evidence for osteocyte regulation of bone homeostasis through RANKL expression

30 September 2017

1 reference

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Matrix-embedded cells control osteoclast formation

30 September 2017

1 reference

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Recent advances on the role of cytokines in atherosclerosis

30 September 2017

1 reference

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Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region

30 September 2017

1 reference

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The mouse RANKL gene locus is defined by a broad pattern of histone H4 acetylation and regulated through distinct distal enhancers

30 September 2017

1 reference

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Increased PTHrP and decreased estrogens alter bone turnover but do not reproduce the full effects of lactation on the skeleton

30 September 2017

1 reference

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Central control of fever and female body temperature by RANKL/RANK

30 September 2017

1 reference

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A novel distal enhancer mediates cytokine induction of mouse RANKl gene expression

30 September 2017

1 reference

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gp130 signaling in bone cell biology: multiple roles revealed by analysis of genetically altered mice.

30 September 2017

1 reference

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The immune response is involved in atherosclerotic plaque calcification: could the RANKL/RANK/OPG system be a marker of plaque instability?

30 September 2017

1 reference

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An enhancer 20 kilobases upstream of the human receptor activator of nuclear factor-kappaB ligand gene mediates dominant activation by 1,25-dihydroxyvitamin D3

30 September 2017

1 reference

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Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass

30 September 2017

1 reference

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Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3.

30 September 2017

1 reference

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Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers

30 September 2017

1 reference

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Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer

30 September 2017

1 reference

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Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization

30 September 2017

1 reference

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Inflammatory bone destruction and osteoimmunology

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1 reference

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Interleukin-11 receptor signaling is required for normal bone remodeling

30 September 2017

1 reference

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The role of the interleukin‐6 family of cytokines in inflammatory arthritis and bone turnover

30 September 2017

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

30 September 2017

1 reference

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Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE

30 September 2017

1 reference

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The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

30 September 2017

1 reference

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Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

30 September 2017

1 reference

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Prostaglandin E2 induces expression of receptor activator of nuclear factor-kappa B ligand/osteoprotegrin ligand on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency

30 September 2017

1 reference

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STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroi

30 September 2017

1 reference

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30 September 2017

1 reference

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30 September 2017

1 reference

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Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis

30 September 2017

1 reference

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30 September 2017

1 reference

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4733116

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4733116

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion

30 September 2017

1 reference

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30 September 2017

1 reference

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Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancers

30 September 2017

1 reference

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28 June 2018

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Distribution and expression of mRNAs for the proto-oncogenes c-fos and c-jun in bone cells in vivo.

28 June 2018

1 reference

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RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation.

28 June 2018

1 reference

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Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

21 September 2018

1 reference

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IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice.

21 September 2018

1 reference

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IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae

21 September 2018

1 reference

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Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation

21 September 2018

1 reference

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Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene

21 September 2018

1 reference

12 December 2020

IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state

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Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice

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A role for interleukin-6 in parathyroid hormone-induced bone resorption in vivo

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12 December 2020

[RANKL signal and osteoimmunology]

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RANKL Induces Organized Lymph Node Growth by Stromal Cell Proliferation

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Expression of membrane-bound and soluble receptor activator of NF-kappaB ligand (RANKL) in human T cells

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The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells

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c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

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Identifiers

DOI

10.1210/EN.2015-1788

1 reference

14 August 2017

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14 August 2017

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