Perspectives on mucus properties and formation--lessons from the biochemical world (Q36526607)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23125206%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Perspectives on mucus properties and formation--lessons from the biochemical world (English)

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17 February 2020

author

Malin E. V. Johansson

2

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17 February 2020

Anna Ermund

4

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17 February 2020

Gunnar C Hansson

5

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17 February 2020

author name string

Daniel Ambort

1

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17 February 2020

Jenny K Gustafsson

3

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17 February 2020

publication date

1 November 2012

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Cold Spring Harbor Perspectives in Medicine

17 February 2020

published in

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17 February 2020

volume

2

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17 February 2020

issue

11

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Supramolecular dynamics of mucus

17 February 2020

cites work

1 reference

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CFTR, mucins, and mucus obstruction in cystic fibrosis

30 September 2017

1 reference

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Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

30 September 2017

1 reference

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Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

30 September 2017

1 reference

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Function of the CysD domain of the gel-forming MUC2 mucin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

30 September 2017

1 reference

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Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion

30 September 2017

1 reference

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von Willebrand factor assembly and secretion

30 September 2017

1 reference

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Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein

30 September 2017

1 reference

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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

30 September 2017

1 reference

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Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

30 September 2017

1 reference

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Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Gel-forming mucins appeared early in metazoan evolution.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Structure and function of the polymeric mucins in airways mucus.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

C-Mannosylation of MUC5AC and MUC5B Cys subdomains

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Evolutionary considerations in relating oligosaccharide diversity to biological function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Human MUC5AC mucin dimerizes in the rough endoplasmic reticulum, similarly to the MUC2 mucin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the 'insoluble' mucin of rat small intestine

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

MUC6 mucin expression inhibits tumor cell invasion.

28 June 2018

1 reference

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A new role for bicarbonate secretion in cervico-uterine mucus release

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn.

21 September 2018

1 reference

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Large scale identification of proteins, mucins, and their O-glycosylation in the endocervical mucus during the menstrual cycle.

21 September 2018

1 reference

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Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543104

Identification of the half-cystine residues in porcine submaxillary mucin critical for multimerization through the D-domains. Roles of the CGLCG motif in the D1- and D3-domains

21 September 2018

1 reference

12 December 2020

Studies on the “Insoluble” Glycoprotein Complex from Human Colon

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12 December 2020

Keeping Bacteria at a Distance

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12 December 2020

The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo

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12 December 2020

Molecular mechanism of mucin secretion: I. The role of intragranular charge shielding

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12 December 2020

10.1101/CSHPERSPECT.A014159

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23125206%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23125206%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference