Dichotomies in cancer research: some suggestions for a new synthesis (Q36529779)

14 August 2017

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title

Dichotomies in cancer research: some suggestions for a new synthesis (English)

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14 August 2017

Michael B Sporn

1

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14 August 2017

1 July 2006

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Nature Clinical Practice Oncology

14 August 2017

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14 August 2017

3

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14 August 2017

7

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14 August 2017

364-373

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Nrf2 as a target for cancer chemoprevention

14 August 2017

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https://api.crossref.org/works/10.1038%2FNCPONC0536

21 January 2018

Cancer statistics, 2006

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPONC0536

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7 January 2021

Cancer chemoprevention: scientific promise, clinical uncertainty

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Precursors to invasive pancreatic cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

The history of cancer epigenetics

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Epigenetics and cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPONC0536

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7 January 2021

Overview of cancer epigenetics

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

It is time for a Human Epigenome Project.

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Points of control in inflammation

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Inflammation and cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Paradoxical roles of the immune system during cancer development

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

The nature of cancer: morphogenesis and progressive (self)-disorganization in neoplastic development and progression

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Inductive tissue interaction in development

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Inductive epitheliomesenchymal interaction in cultured organ rudiments of the mouse

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Induction of nuclear androgen-binding sites in epithelium of the embryonic urinary bladder by mesenchyme of the urogenital sinus of embryonic mice

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

How does the extracellular matrix direct gene expression?

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Stromal fibroblasts in cancer initiation and progression

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Mechanisms of aflatoxin carcinogenesis

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

The development of imatinib as a therapeutic agent for chronic myeloid leukemia

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Targeted therapies in breast cancer.

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Multiple mutations and cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Chromosomal translocations in human cancer.

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Retinoids in cancer therapy and chemoprevention: promise meets resistance

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Validating Stat3 in cancer therapy

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

STAT proteins as novel targets for cancer drug discovery

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Transcription factors as targets for cancer therapy

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

NF-kappaB: linking inflammation and immunity to cancer development and progression

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Nrf2: a potential molecular target for cancer chemoprevention by natural compounds

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Teratocarcinomas and other neoplasms as developmental defects in gene expression.

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Myc pathways provoking cell suicide and cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

TGF-beta signaling: positive and negative effects on tumorigenesis

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

KLF4, p21 and context-dependent opposing forces in cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Coregulator function: a key to understanding tissue specificity of selective receptor modulators

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

The language of covalent histone modifications

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Binary switches and modification cassettes in histone biology and beyond.

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Oscillations in NF-kappaB signaling control the dynamics of gene expression

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

High-throughput mapping of a dynamic signaling network in mammalian cells

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Functional proteomics mapping of a human signaling pathway

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

A human protein-protein interaction network: a resource for annotating the proteome

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Grasping at molecular interactions and genetic networks in Drosophila melanogaster using FlyNets, an Internet database

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Somatic mutations of the protein kinase gene family in human lung cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

The electrophile counterattack response: protection against neoplasia and toxicity.

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Cancer chemoprevention with dietary phytochemicals

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Chemoprevention: an essential approach to controlling cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

The profit problem in antibiotic R&D

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Antibiotics at the crossroads

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Herceptin: HERalding a new era in breast cancer care but at what cost?

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https://api.crossref.org/works/10.1038%2FNCPONC0536

7 January 2021

Identifiers

DOI

10.1038/NCPONC0536

1 reference

14 August 2017

1 reference

PubMed ID

16826217