Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. (Q36532572)

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17 February 2020

title

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex (English)

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17 February 2020

9

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George Poulogiannis

3

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11

John Blenis

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17 February 2020

author name string

Sang Gyun Kim

1

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Gregory R Hoffman

2

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Gwen R Buel

4

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Young Jin Jang

5

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Ki Won Lee

6

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17 February 2020

Bo-Yeon Kim

7

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Raymond L Erikson

8

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Andrew Y Choo

10

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publication date

8 November 2012

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17 February 2020

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17 February 2020

volume

49

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issue

1

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17 February 2020

page(s)

172-185

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Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

17 February 2020

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Structure of the human mTOR complex I and its implications for rapamycin inhibition.

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

30 September 2017

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Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly

30 September 2017

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

30 September 2017

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AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

30 September 2017

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A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique

30 September 2017

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

30 September 2017

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Regulation of TORC1 by Rag GTPases in nutrient response

30 September 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

30 September 2017

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

30 September 2017

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Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

30 September 2017

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Tel2 regulates the stability of PI3K-related protein kinases

30 September 2017

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

30 September 2017

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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10.1016/J.MOLCEL.2012.10.003

21 September 2018

Identifiers

DOI

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17 February 2020

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17 February 2020

PubMed publication ID

23142078

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