Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway (Q28646919)

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English	Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway	scientific journal article

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scholarly article

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12150915%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway (English)

2 references

3 February 2017

Europe PubMed Central

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11 November 2019

tuberous sclerosis

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inferred from title

2

1 reference

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11 November 2019

author name string

John Blenis

4

2 references

3 February 2017

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11 November 2019

Brendan D Manning

1

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11 November 2019

M Nicole Logsdon

3

1 reference

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11 November 2019

Lewis C Cantley

5

1 reference

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11 November 2019

publication date

1 July 2002

2 references

3 February 2017

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11 November 2019

2 references

3 February 2017

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11 November 2019

10

2 references

3 February 2017

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11 November 2019

151-162

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11 November 2019

1

2 references

3 February 2017

Europe PubMed Central

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11 November 2019

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian TOR: a homeostatic ATP sensor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Determination of the specific substrate sequence motifs of protein kinase C isozymes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of phosphoinositide 3-kinase lipid products in cell function

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

PI 3-kinase, mTOR, protein synthesis and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple independent inputs are required for activation of the p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900568-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1097-2765(02)00568-3

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12150915%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12150915%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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