The role of iron regulatory proteins in mammalian iron homeostasis and disease (Q36540433)

14 August 2017

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title

The role of iron regulatory proteins in mammalian iron homeostasis and disease (English)

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14 August 2017

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Tracey A Rouault

1

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14 August 2017

1 August 2006

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14 August 2017

Nature Chemical Biology

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14 August 2017

2

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14 August 2017

406-414

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14 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nchembio807

14 August 2017

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The aconitase family: three structural variations on a common theme

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Aconitase as Ironminus signSulfur Protein, Enzyme, and Iron-Regulatory Protein

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7 January 2021

Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins

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7 January 2021

Iron regulatory element and internal loop/bulge structure for ferritin mRNA studied by cobalt(III) hexammine binding, molecular modeling, and NMR spectroscopy

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7 January 2021

The influence of the base-paired flanking region on structure and function of the ferritin mRNA iron regulatory element

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7 January 2021

Clinical severity and thermodynamic effects of iron-responsive element mutations in hereditary hyperferritinemia-cataract syndrome

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7 January 2021

Iron regulatory proteins 1 and 2 bind distinct sets of RNA target sequences

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Differences in the RNA binding sites of iron regulatory proteins and potential target diversity

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

The hairpin loop but not the bulged C of the iron responsive element is essential for high affinity binding to iron regulatory protein-1

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Translational regulation of mRNAs with distinct IRE sequences by iron regulatory proteins 1 and 2

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Loops and bulge/loops in iron-responsive element isoforms influence iron regulatory protein binding. Fine-tuning of mRNA regulation?

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Combinatorial mRNA regulation: iron regulatory proteins and iso-iron-responsive elements (Iso-IREs).

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Hereditary hyperferritinemia cataract syndrome: ocular, genetic, and biochemical findings

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Iron differentially stimulates translation of mitochondrial aconitase and ferritin mRNAs in mammalian cells. Implications for iron regulatory proteins as regulators of mitochondrial citrate utilization

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Succinate dehydrogenase b mRNA of Drosophila melanogaster has a functional iron-responsive element in its 5'-untranslated region

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7 January 2021

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Iron-dependent regulation of the divalent metal ion transporter

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Oxidative stress-mediated down-regulation of rat hydroxyacid oxidase 1, a liver-specific peroxisomal enzyme

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Expression of active iron regulatory factor from a full length human cDNA byin vitrotranscription/translation

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

A regulated RNA binding protein also possesses aconitase activity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Crystal structure of human iron regulatory protein 1 as cytosolic aconitase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

The structure of aconitase

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Modulation of cellular iron metabolism by hydrogen peroxide. Effects of H2O2 on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

The iron-responsive element-binding protein: localization of the RNA-binding site to the aconitase active-site cleft

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Identification of RNA-binding surfaces in iron regulatory protein-1.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Ligand-induced Structural Alterations in Human Iron Regulatory Protein-1 Revealed by Protein Footprinting

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Crystallization and preliminary X-ray diffraction analysis of iron regulatory protein 1 in complex with ferritin IRE RNA.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Iron regulatory proteins and the molecular control of mammalian iron metabolism

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Structure, function, and formation of biological iron-sulfur clusters

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Iron-sulfur-protein biogenesis in eukaryotes

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Prokaryotic and eukaryotic monothiol glutaredoxins are able to perform the functions of Grx5 in the biogenesis of Fe/S clusters in yeast mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Linking physiological functions of iron

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Nitric oxide and peroxynitrite activate the iron regulatory protein-1 of J774A.1 macrophages by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

IRP1 activation by extracellular oxidative stress in the perfused rat liver

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Compartment-specific protection of iron-sulfur proteins by superoxide dismutase

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Detection of a [3Fe-4S] cluster intermediate of cytosolic aconitase in yeast expressing iron regulatory protein 1. Insights into the mechanism of Fe-S cluster cycling

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Endogenous nitration of iron regulatory protein-1 (IRP-1) in nitric oxide-producing murine macrophages: further insight into the mechanism of nitration in vivo and its impact on IRP-1 functions

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Dietary iron intake modulates the activity of iron regulatory proteins and the abundance of ferritin and mitochondrial aconitase in rat liver

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Effect of micromolar Ca2+ on NADH inhibition of bovine kidney alpha-ketoglutarate dehydrogenase complex and possible role of Ca2+ in signal amplification

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Mitochondrial metabolite transporters.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Identification of a heme-sensing domain in iron regulatory protein 2.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Oxygen and iron regulation of iron regulatory protein 2.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Phosphorylation and activation of both iron regulatory proteins 1 and 2 in HL-60 cells

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO807

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO807

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14 August 2017

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PubMed ID

16850017