Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart. (Q36540577)

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21 February 2020

title

Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart (English)

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21 February 2020

9

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21 February 2020

author name string

Marie A Schroeder

1

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21 February 2020

Angus Z Lau

2

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21 February 2020

Albert P Chen

3

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21 February 2020

Yiping Gu

4

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21 February 2020

Jeevan Nagendran

5

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21 February 2020

Jennifer Barry

6

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21 February 2020

Xudong Hu

7

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21 February 2020

Jason R B Dyck

8

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21 February 2020

Kieran Clarke

10

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21 February 2020

Kim A Connelly

11

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21 February 2020

Graham A Wright

12

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21 February 2020

Charles H Cunningham

13

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21 February 2020

publication date

19 December 2012

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European Journal of Heart Failure

21 February 2020

published in

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21 February 2020

volume

15

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21 February 2020

issue

2

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21 February 2020

page(s)

130-140

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Targeting myocardial substrate metabolism in heart failure: potential for new therapies

21 February 2020

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Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease.

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Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy

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Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR.

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Myocardial substrate metabolism in the normal and failing heart

30 September 2017

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Is the failing heart energy starved? On using chemical energy to support cardiac function

30 September 2017

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Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR

30 September 2017

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Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells

30 September 2017

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An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure.

30 September 2017

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The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase

30 September 2017

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The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

30 September 2017

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Cardiac and skeletal muscle insulin resistance in patients with coronary heart disease. A study with positron emission tomography

30 September 2017

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Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo

30 September 2017

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Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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Upregulation of the cardiac monocarboxylate transporter MCT1 in a rat model of congestive heart failure

21 September 2018

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21 September 2018

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Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine

21 September 2018

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12 December 2020

The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study

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12 December 2020

31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Altered cardiac high-energy phosphate metabolism in heart failure

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12 December 2020

Altered pyruvate dehydrogenase control and mitochondrial free Ca2+ in hearts of cardiomyopathic hamsters

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12 December 2020

Fatty acid oxidation enzyme gene expression is downregulated in the failing heart

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12 December 2020

Time to address the cardiac metabolic "triple whammy" ischemic heart failure in diabetic patients

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12 December 2020

Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts

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12 December 2020

Identifiers

DOI

10.1093/EURJHF/HFS192

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258802%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

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21 February 2020

PubMed publication ID

23258802

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258802%20AND%20SRC:MED&resulttype=core&format=json