Ligand-targeted delivery of therapeutic siRNA. (Q36540601)

14 August 2017

1 reference

title

Ligand-targeted delivery of therapeutic siRNA. (English)

1 reference

14 August 2017

Yutaka Ikeda

1

1 reference

PubMed ID

16850274

14 August 2017

Kazunari Taira

series ordinal

2

1 reference

14 August 2017

1 August 2006

1 reference

14 August 2017

Pharmaceutical Research

1 reference

14 August 2017

23

1 reference

14 August 2017

8

1 reference

14 August 2017

1631-1640

1 reference

Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma

14 August 2017

1 reference

12 December 2020

RNA interference in mammalian cells by chemically-modified RNA.

1 reference

12 December 2020

Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms

1 reference

12 December 2020

A New Self-Assembling System for Targeted Gene Delivery

1 reference

12 December 2020

Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses

1 reference

12 December 2020

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 reference

12 December 2020

Monoclonal antibody therapy of cancer

1 reference

12 December 2020

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

1 reference

12 December 2020

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake

1 reference

12 December 2020

Supraagonistic, bispecific single-chain antibody purified from the serum of cloned, transgenic cows induces T-cell-mediated killing of glioblastoma cells in vitro and in vivo.

1 reference

12 December 2020

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

1 reference

12 December 2020

An efficient route to human bispecific IgG.

1 reference

12 December 2020

Can nuclear localization signals enhance nuclear localization of plasmid DNA?

1 reference

12 December 2020

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors

1 reference

12 December 2020

Bispecific and bifunctional single chain recombinant antibodies

1 reference

12 December 2020

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays

1 reference

12 December 2020

Therapeutic antibody fragments with prolonged in vivo half-lives

1 reference

12 December 2020

Single-chain antibody-mediated gene delivery into ErbB2-positive human breast cancer cells

1 reference

12 December 2020

Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells

1 reference

12 December 2020

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

1 reference

12 December 2020

Delivery of siRNA and siRNA expression constructs to adult mammals by hydrodynamic intravascular injection

1 reference

12 December 2020

Challenges for RNAi in vivo

1 reference

12 December 2020

The genetics and genomics of cancer

1 reference

12 December 2020

PEGylated antibodies and antibody fragments for improved therapy: a review

1 reference

12 December 2020

Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus

1 reference

12 December 2020

Selection of tumor-specific internalizing human antibodies from phage libraries

1 reference

12 December 2020

Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol

1 reference

12 December 2020

Specific 3'-terminal modification of DNA with a novel nucleoside analogue that allows a covalent linkage of a nuclear localization signal and enhancement of DNA stability

1 reference

12 December 2020

Novel method for covalent fluorescent labeling of plasmid DNA that maintains structural integrity of the plasmid.

1 reference

12 December 2020

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct.

1 reference

12 December 2020

The use of mRNA display to select high-affinity protein-binding peptides

1 reference

12 December 2020

Tolerance for mutations and chemical modifications in a siRNA.

1 reference

12 December 2020

Tat-mediated delivery of heterologous proteins into cells

1 reference

12 December 2020

Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity

1 reference

12 December 2020

In vivo protein transduction: delivery of a biologically active protein into the mouse

1 reference

12 December 2020

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

1 reference

12 December 2020

Effect of glycosylation on antibody function: implications for genetic engineering

1 reference

12 December 2020

Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation

1 reference

12 December 2020

RNA interference using boranophosphate siRNAs: structure-activity relationships

1 reference

12 December 2020

Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody

1 reference

12 December 2020

Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery

1 reference

12 December 2020

Improved tumor targeting with chemically cross-linked recombinant antibody fragments

1 reference

12 December 2020

A novel strategy by the action of ricin that connects phenotype and genotype without loss of the diversity of libraries.

1 reference

12 December 2020

Cell-specific delivery of genes with glycosylated carriers

1 reference

12 December 2020

Arming antibodies: prospects and challenges for immunoconjugates

1 reference

12 December 2020

"Diabodies": small bivalent and bispecific antibody fragments

1 reference

12 December 2020

Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display

1 reference

12 December 2020

Tumour targeting of humanised cross-linked divalent-Fab' antibody fragments: a clinical phase I/II study

1 reference

12 December 2020

Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte-derived macrophages

1 reference

12 December 2020

Biodistribution of phosphodiester and phosphorothioate siRNA.

1 reference

12 December 2020

Conjugation of plasmid DNAs with lactose via diazocoupling enhances resistance to restriction enzymes and acquires binding affinity to galactose-specific lectin

1 reference

12 December 2020

Transferrin receptor 1.

1 reference

12 December 2020

Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors

1 reference

12 December 2020

siRNA function in RNAi: a chemical modification analysis

1 reference

12 December 2020

Visualizing a Correlation between siRNA Localization, Cellular Uptake, and RNAi in Living Cells

1 reference

12 December 2020

Protein drug stability: a formulation challenge

1 reference

12 December 2020

Modified peptide selection in vitro by introduction of a protein-RNA interaction.

1 reference

12 December 2020

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

1 reference

12 December 2020

Positional effect of chemical modifications on short interference RNA activity in mammalian cells

1 reference

12 December 2020

Substrate Specificity and Kinetics of Degradation of Antisense Oligonucleotides by a 3′ Exonuclease in Plasma

1 reference

12 December 2020

Mapping tumor epitope space by direct selection of single-chain Fv antibody libraries on prostate cancer cells

1 reference

12 December 2020

Formatting antibody fragments to mediate specific therapeutic functions

1 reference

12 December 2020

Effect of cationic charge on receptor-mediated transfection using mannosylated cationic liposome/plasmid DNA complexes following the intravenous administration in mice.

1 reference

12 December 2020

A system based on specific protein-RNA interactions for analysis of target protein-protein interactions in vitro: successful selection of membrane-bound Bak-Bcl-xL proteins in vitro

1 reference

12 December 2020

Novel approach for linking genotype to phenotype in vitro by exploiting an extremely strong interaction between RNA and protein

1 reference

12 December 2020

RNA interference in adult mice.

1 reference

12 December 2020

Engineered antibodies

1 reference

12 December 2020

Methods for generating multivalent and bispecific antibody fragments

1 reference

12 December 2020

Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications

1 reference

12 December 2020

1 reference

12 December 2020

Engineered antibody fragments and the rise of single domains

1 reference

12 December 2020

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

1 reference

12 December 2020

The silent revolution: RNA interference as basic biology, research tool, and therapeutic

1 reference

12 December 2020

Enhancement of immune responses by DNA vaccination through targeted gene delivery using mannosylated cationic liposome formulations following intravenous administration in mice

1 reference

12 December 2020

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure

1 reference

12 December 2020

Protein PEGylation decreases observed target association rates via a dual blocking mechanism

1 reference

12 December 2020

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

1 reference

12 December 2020

Liposomal and viral vectors for gene therapy of the central nervous system.

1 reference

12 December 2020

Engineering novel binding proteins from nonimmunoglobulin domains

1 reference

12 December 2020

Combined effect of recombinant CD19 x CD16 diabody and thalidomide in a preclinical model of human B cell lymphoma

1 reference

12 December 2020

In vivo gene delivery to the liver using novel galactosylated cationic liposomes

1 reference

12 December 2020

Target-specific gene silencing by siRNA plasmid DNA complexed with folate-modified poly(ethylenimine).

1 reference

12 December 2020

Phage display vectors for the in vitro generation of human antibody fragments.

1 reference

12 December 2020

Tat Peptide-Mediated Intracellular Delivery of Liposomes

1 reference

12 December 2020

Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.

1 reference

12 December 2020

Collagen-binding integrins as pharmaceutical targets

1 reference

12 December 2020

High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules

1 reference

12 December 2020

Phage display-derived peptides as therapeutic alternatives to antibodies

1 reference

12 December 2020

Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells

1 reference

12 December 2020

Small-interfering-RNA expression in cells based on an efficiently constructed dumbbell-shaped DNA.

1 reference

12 December 2020

10.1007/S11095-006-9001-X

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16850274