Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition (Q36544905)

14 August 2017

1 reference

title

Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition (English)

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14 August 2017

3

Heyo K Kroemer

1 reference

14 August 2017

Gabriele Jedlitschky

1

1 reference

PubMed ID

16863439

14 August 2017

Ulrich Hoffmann

series ordinal

2

1 reference

PubMed ID

16863439

14 August 2017

language of work or name

English

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publication date

1 June 2006

1 reference

Expert Opinion on Drug Metabolism & Toxicology

14 August 2017

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14 August 2017

2

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14 August 2017

3

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14 August 2017

351-366

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The human ATP-binding cassette (ABC) transporter superfamily

14 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Multifunctionality of plant ABC transporters--more than just detoxifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Type 1 protein secretion in bacteria, the ABC-transporter dependent pathway (review).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Mammalian ABC transporters in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

The MRP family of drug efflux pumps

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with a report of 12 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

ABC of oral bioavailability: transporters as gatekeepers in the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Drug resistance in brain diseases and the role of drug efflux transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Brain access and anticonvulsant efficacy of carbamazepine, lamotrigine, and felbamate in ABCC2/MRP2-deficient TR- rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Differential function of the two nucleotide binding domains on cystic fibrosis transmembrane conductance regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Role of glycosylation in trafficking of Mrp2 in sandwich-cultured rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Uptake and efflux transporters for conjugates in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Mrp2 is involved in benzylpenicillin-induced choleresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR-) hyperbilirubinemic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Role of Multidrug Resistance Protein 2 (MRP2, ABCC2) in Alkylating Agent Detoxification: MRP2 Potentiates GlutathioneS-Transferase A1-1-Mediated Resistance to Chlorambucil Cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

ABCC2-mediated biliary transport of 4-glutathionylcyclophosphamide and its contribution to elimination of 4-hydroxycyclophosphamide in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Characterization of secretory intestinal transport of the lactone form of CPT-11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Ochratoxin A: the continuing enigma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Ochratoxin a: its cancer risk and potential for exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Enteric excretion of baicalein, a flavone of Scutellariae Radix, via glucuronidation in rat: involvement of multidrug resistance-associated protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Transport of toxic metals by molecular mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Formation and urinary excretion of arsenic triglutathione and methylarsenic diglutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Arsenic speciation in bile and urine following oral and intravenous exposure to inorganic and organic arsenics in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Endogenous thiols and MRP transporters contribute to Hg2+ efflux in HgCl2-treated tubular MDCK cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

The effect of rifampin treatment on intestinal expression of human MRP transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Intracellular trafficking and regulation of canalicular ATP-binding cassette transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide-induced cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

ABC transporters in the balance: is there a role in multidrug resistance?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.351

21 January 2018

Identifiers

DOI

10.1517/17425255.2.3.351

1 reference

14 August 2017

1 reference

PubMed ID

16863439