Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation (Q36551384)

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scientific article published on June 1995

Language	Label	Description	Also known as
English	Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation	scientific article published on June 1995

Statements

scholarly article

1 reference

Europe PubMed Central

14 August 2017

Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation (English)

1 reference

Europe PubMed Central

14 August 2017

author name string

G N Barber

1

1 reference

Europe PubMed Central

14 August 2017

M Wambach

2

1 reference

Europe PubMed Central

14 August 2017

S Thompson

3

1 reference

Europe PubMed Central

14 August 2017

R Jagus

4

1 reference

Europe PubMed Central

14 August 2017

M G Katze

5

1 reference

Europe PubMed Central

14 August 2017

language of work or name

0 references

publication date

1 June 1995

1 reference

Europe PubMed Central

14 August 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

14 August 2017

15

1 reference

Europe PubMed Central

14 August 2017

6

1 reference

Europe PubMed Central

14 August 2017

3138-3146

1 reference

Europe PubMed Central

14 August 2017

Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase

1 reference

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30 September 2017

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase

1 reference

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30 September 2017

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

1 reference

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The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans

1 reference

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30 September 2017

Activation of the double-stranded RNA (dsRNA)-activated human protein kinase in vivo in the absence of its dsRNA binding domain

1 reference

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30 September 2017

Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase

1 reference

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30 September 2017

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1 reference

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Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae

1 reference

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30 September 2017

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR

1 reference

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30 September 2017

Chromosomal assignment of the interferon-inducible double-stranded RNA-dependent protein kinase (PRKR) to human chromosome 2p21-p22 and mouse chromosome 17 E2

1 reference

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30 September 2017

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

1 reference

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30 September 2017

Regulation of the interferon-induced PKR: can viruses cope?

1 reference

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30 September 2017

Role of the amino-terminal residues of the interferon-induced protein kinase in its activation by double-stranded RNA and heparin

1 reference

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30 September 2017

The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

30 September 2017

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

30 September 2017

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells

1 reference

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30 September 2017

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity

1 reference

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30 September 2017

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation.

1 reference

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30 September 2017

An analysis of vertebrate mRNA sequences: intimations of translational control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

30 September 2017

Translational control in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

30 September 2017

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1 reference

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30 September 2017

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

30 September 2017

Interferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2',5'-oligoadenylate synthetases

1 reference

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30 September 2017

The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

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Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1 reference

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30 September 2017

Binding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI.

1 reference

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Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions

1 reference

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30 September 2017

A conserved double-stranded RNA-binding domain

1 reference

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Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

1 reference

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30 September 2017

Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase

1 reference

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The interferon system. A bird's eye view of its biochemistry

1 reference

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30 September 2017

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

30 September 2017

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2

1 reference

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Thyroid Hormone Receptor Transcriptional Activity Is Potentially Autoregulated by Truncated Forms of the Receptor

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Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells

1 reference

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30 September 2017

Mechanism of interferon action motif I of the interferon-induced, RNA-dependent protein kinase (PKR) is sufficient to mediate RNA-binding activity

1 reference

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Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VA RNA.

1 reference

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CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

28 June 2018

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

28 June 2018

Cytosolic double-stranded RNA-dependent protein kinase is likely a dimer of partially phosphorylated Mr = 66,000 subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

28 June 2018

Detection of protein kinase homologues and viral RNA-binding domains utilizing polyclonal antiserum prepared against a baculovirus-expressed ds RNA-activated 68,000-Da protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

28 June 2018

Interactions between double-stranded RNA regulators and the protein kinase DAI

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230545

28 June 2018

Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7539103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The double-stranded RNA-dependent protein kinase is also activated by heparin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7539103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophosphorylation of the protein kinase dependent on double-stranded RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/7539103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/7539103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI

1 reference

https://pubmed.ncbi.nlm.nih.gov/7539103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras

1 reference

https://pubmed.ncbi.nlm.nih.gov/7539103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.15.6.3138

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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