New pathways in drug discovery for Alzheimer's disease (Q36575004)

15 August 2017

1 reference

title

New pathways in drug discovery for Alzheimer's disease (English)

1 reference

15 August 2017

0 references

1 reference

Eric R Siemers

1

1 reference

15 August 2017

Robert A Dean

series ordinal

2

1 reference

15 August 2017

Ronald Demattos

series ordinal

3

1 reference

15 August 2017

Patrick C May

series ordinal

4

1 reference

15 August 2017

1 September 2006

1 reference

Current Neurology and Neuroscience Reports

15 August 2017

1 reference

15 August 2017

6

1 reference

15 August 2017

5

1 reference

15 August 2017

372-378

1 reference

https://scigraph.springernature.com/pub.10.1007/s11910-996-0017-8

15 August 2017

0 references

cites work

The natural history of Alzheimer's disease: a brain bank study

1 reference

https://api.crossref.org/works/10.1007%2FS11910-996-0017-8

Alzheimer disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-996-0017-8

Translating cell biology into therapeutic advances in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-996-0017-8

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-996-0017-8

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-996-0017-8

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-996-0017-8

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

12 December 2020

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

1 reference

12 December 2020

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

1 reference

12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

12 December 2020

Selective loss of central cholinergic neurons in Alzheimer's disease

1 reference

12 December 2020

Glycosaminoglycans and beta-amyloid, prion and tau peptides in neurodegenerative diseases

1 reference

12 December 2020

Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology.

1 reference

12 December 2020

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

1 reference

12 December 2020

Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease

1 reference

12 December 2020

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Perspective on a pathogenesis and treatment of Alzheimer's disease.

1 reference

12 December 2020

Imaging-based measures of disease progression in clinical trials of disease-modifying drugs for Alzheimer disease

1 reference

12 December 2020

Optimal design of clinical trials for drugs designed to slow the course of Alzheimer's disease

1 reference

12 December 2020

Cerebral hemorrhage after passive anti-Abeta immunotherapy.

1 reference

12 December 2020

1 reference

12 December 2020

The role of biomarkers in clinical trials for Alzheimer disease

1 reference

12 December 2020

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

1 reference

12 December 2020

Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.

1 reference

12 December 2020

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

12 December 2020

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

12 December 2020

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

12 December 2020

The development of anti-amyloid therapy for Alzheimer's disease : from secretase modulators to polymerisation inhibitors

1 reference

12 December 2020

The metallobiology of Alzheimer's disease

1 reference

12 December 2020

Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease

1 reference

12 December 2020

Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

1 reference

12 December 2020

CSF markers for incipient Alzheimer's disease

1 reference

12 December 2020

Prospective analysis of risk factors for nursing home placement of dementia patients

1 reference

12 December 2020

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

1 reference

12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

12 December 2020

Neuropathological stageing of Alzheimer-related changes

1 reference

12 December 2020

Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.

1 reference

12 December 2020

Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

1 reference

12 December 2020

beta-peptide immunization: a possible new treatment for Alzheimer disease

1 reference

12 December 2020

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

1 reference

12 December 2020

Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development

1 reference

12 December 2020

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion

1 reference

12 December 2020

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

1 reference

12 December 2020

Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

12 December 2020

Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol

1 reference

12 December 2020

Treatment of Alzheimer's disease with cholinesterase inhibitors

1 reference

12 December 2020

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

1 reference

12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

12 December 2020

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

12 December 2020

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

12 December 2020

Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures

1 reference

12 December 2020

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

1 reference

12 December 2020

Commentary on "Optimal design of clinical trials for drugs designed to slow the course of Alzheimer's disease"

1 reference

12 December 2020

Evolution of the neuropathology of Alzheimer's disease.

1 reference

12 December 2020

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

1 reference

12 December 2020

Therapeutic approaches related to amyloid-beta peptide and Alzheimer's disease

1 reference

12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

12 December 2020

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors

1 reference

12 December 2020

10.1007/S11910-996-0017-8

Identifiers

DOI

1 reference

15 August 2017

1 reference