Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase (Q36580508)

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scientific article published on 10 December 2007

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English	Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase	scientific article published on 10 December 2007

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scholarly article

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30 December 2019

Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase (English)

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30 December 2019

Toxoplasma gondii

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Trypanosoma cruzi

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Sergio Hernán Szajnman

1

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30 December 2019

Juan B. Rodríguez

10

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30 December 2019

5

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Melina Galizzi

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30 December 2019

Roberto Docampo

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Roberto Docampo

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30 December 2019

Silvia N J Moreno

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Silvia N J Moreno

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30 December 2019

author name string

Guadalupe E García Liñares

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30 December 2019

Zhu-Hong Li

3

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30 December 2019

Cuiying Jiang

4

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30 December 2019

Esteban J Bontempi

6

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30 December 2019

Marcela Ferella

7

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30 December 2019

language of work or name

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publication date

10 December 2007

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30 December 2019

Bioorganic & Medicinal Chemistry

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30 December 2019

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30 December 2019

3283-3290

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30 December 2019

6

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30 December 2019

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

1 reference

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9 September 2017

Progresses in the field of drug design to combat tropical protozoan parasitic diseases

1 reference

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9 September 2017

Nitrogen-containing bisphosphonate mechanism of action.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

9 September 2017

Specific chemotherapy of Chagas disease: controversies and advances

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Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

1 reference

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9 September 2017

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

1 reference

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9 September 2017

High-throughput growth assay for Toxoplasma gondii using yellow fluorescent protein

1 reference

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9 September 2017

Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites

1 reference

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9 September 2017

Chemotherapy of Chagas disease

1 reference

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9 September 2017

Recent developments in the chemotherapy of Chagas disease.

1 reference

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9 September 2017

Molecular mechanisms of action of bisphosphonates.

1 reference

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9 September 2017

Regulation of product chain length by isoprenyl diphosphate synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

9 September 2017

Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

30 September 2017

Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

30 September 2017

Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

30 September 2017

Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

30 September 2017

Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

30 September 2017

Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

30 September 2017

The challenge of Chagas' disease chemotherapy: an update of drugs assayed against Trypanosoma cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

30 September 2017

Cell Biology of Trypanosoma cruzi

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30 September 2017

Biology of Trypanosoma cruzi

1 reference

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30 September 2017

Vacuolar proton pyrophosphatase activity and pyrophosphate (PPi) in Toxoplasma gondii as possible chemotherapeutic targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

28 June 2018

The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

20 September 2018

A solanesyl-diphosphate synthase localizes in glycosomes of Trypanosoma cruzi.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

20 September 2018

Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

20 September 2018

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

1 reference

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20 September 2018

Risedronate in the treatment of Murine Chagas' disease

1 reference

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20 September 2018

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

20 September 2018

Activity of bisphosphonates against Trypanosoma brucei rhodesiense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

20 September 2018

Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

20 September 2018

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2330165

20 September 2018

A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation.

1 reference

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20 September 2018

Risk factors for Trypanosoma cruzi infection in California blood donors

1 reference

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20 September 2018

Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs

1 reference

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21 October 2018

[Effect of triphenylmethane dyes on Trypanosoma cruzi in vitro; use of gentian violet in prevention of transmission of Chagas disease by blood transfusion]

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4 December 2018

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18096393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure−Activity Relationship of New Growth Inhibitors ofTrypanosomacruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/18096393

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMC.2007.12.010

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30 December 2019

1 reference

Europe PubMed Central

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30 December 2019

1 reference

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30 December 2019

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