Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine (Q36580716)

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3 January 2020

title

Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine (English)

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3 January 2020

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3

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3 January 2020

Aaron M Korkegian

2

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3 January 2020

author name string

Tiffany S Stolworthy

1

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3 January 2020

Andressa Ardiani

4

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3 January 2020

Jennifer Cundiff

5

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3 January 2020

Barry L Stoddard

6

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3 January 2020

Margaret E Black

7

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3 January 2020

language of work or name

English

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publication date

11 January 2008

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Journal of Molecular Biology

3 January 2020

published in

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3 January 2020

volume

377

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3 January 2020

issue

3

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3 January 2020

page(s)

854-869

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Mesophile versus thermophile: insights into the structural mechanisms of kinetic stability

3 January 2020

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Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine.

9 September 2017

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The crystal structure of citrate synthase from the hyperthermophilic archaeon pyrococcus furiosus at 1.9 A resolution,

9 September 2017

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Crystal structures of Escherichia coli and Salmonella typhimurium 3-isopropylmalate dehydrogenase and comparison with their thermophilic counterpart from Thermus thermophilus

9 September 2017

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The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures

9 September 2017

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9 September 2017

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Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy

9 September 2017

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Evidence for conversion of 5-fluorocytosine to 5-fluorouracil in humans: possible factor in 5-fluorocytosine clinical toxicity

9 September 2017

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Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma

9 September 2017

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A guanylate kinase/HSV-1 thymidine kinase fusion protein enhances prodrug-mediated cell killing.

30 September 2017

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Second-generation replication-competent oncolytic adenovirus armed with improved suicide genes and ADP gene demonstrates greater efficacy without increased toxicity

30 September 2017

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Engineering conditionally replication-competent adenoviral vectors carrying the cytosine deaminase gene increases the infectivity and therapeutic effect for breast cancer gene therapy

30 September 2017

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Insights into the molecular basis of thermal stability from the structure determination of Pyrococcus furiosus glutamate dehydrogenase

30 September 2017

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30 September 2017

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Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line

30 September 2017

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The structure of a thermally stable 3-phosphoglycerate kinase and a comparison with its mesophilic equivalent

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Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase

20 September 2018

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20 September 2018

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20 September 2018

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Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate canc

20 September 2018

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Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing

20 September 2018

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Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer

20 September 2018

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Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing

20 September 2018

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Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts

20 September 2018

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In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene

20 September 2018

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Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models

20 September 2018

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Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine

20 September 2018

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Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts

20 September 2018

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20 September 2018

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20 September 2018

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Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity

20 September 2018

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20 September 2018

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Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model

20 September 2018

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

The inhibitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro

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12 December 2020

Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects

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12 December 2020

5-fluorouracil: a pharmacological paradigm in the use of cytotoxics

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12 December 2020

Bystander effect caused by cytosine deaminase gene and 5-fluorocytosine in vitro is substantially mediated by generated 5-fluorouracil

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12 December 2020

10.1016/J.JMB.2008.01.002

Identifiers

DOI

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3 January 2020

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3 January 2020

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