On the molecular basis linking Nerve Growth Factor (NGF) to Alzheimer's disease (Q36582363)

15 August 2017

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title

On the molecular basis linking Nerve Growth Factor (NGF) to Alzheimer's disease (English)

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15 August 2017

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Simona Capsoni

1

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PubMed ID

16944323

15 August 2017

Antonino Cattaneo

series ordinal

2

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15 August 2017

1 July 2006

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Cellular and Molecular Neurobiology

15 August 2017

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15 August 2017

26

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15 August 2017

4-6

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15 August 2017

619-633

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https://scigraph.springernature.com/pub.10.1007/s10571-006-9112-2

15 August 2017

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cites work

Tau, tangles, and Alzheimer's disease

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https://api.crossref.org/works/10.1007%2FS10571-006-9112-2

Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9112-2

Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9112-2

Tau pathology in Alzheimer disease and other tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9112-2

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9112-2

Trk neurotrophin receptors in cholinergic neurons of patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9112-2

Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections

21 January 2018

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12 December 2020

Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases

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12 December 2020

Early days of the nerve growth factor proteins.

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12 December 2020

Human nerve growth factor improves spatial memory in aged but not in young rats.

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12 December 2020

Traffic at the intersection of neurotrophic factor signaling and neurodegeneration

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12 December 2020

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.

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12 December 2020

Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice

1 reference

12 December 2020

Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease

1 reference

12 December 2020

Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies

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12 December 2020

Human beta-nerve growth factor gene sequence highly homologous to that of mouse

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12 December 2020

Purification and metabolic effects of a nerve growth-promoting protein from snake venom

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12 December 2020

Neuroantibodies: ectopic expression of a recombinant anti-substance P antibody in the central nervous system of transgenic mice.

1 reference

12 December 2020

Disruption of cysteine-rich repeats of the p75 nerve growth factor receptor leads to loss of ligand binding.

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12 December 2020

Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey.

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12 December 2020

Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates

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12 December 2020

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75

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12 December 2020

Structure, microtubule interactions, and phosphorylation of tau protein

1 reference

12 December 2020

Three distinct types of monoclonal antibodies after long-term immunization of rats with mouse nerve growth factor

1 reference

12 December 2020

Cloning and expression of an anti-nerve growth factor (NGF) antibody for studies using the neuroantibody approach.

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12 December 2020

Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury

1 reference

12 December 2020

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease

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12 December 2020

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease

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12 December 2020

Nerve growth factor mediates signal transduction through trk homodimer receptors

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12 December 2020

Gene transfer and molecular cloning of the human NGF receptor.

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12 December 2020

Trk receptors: roles in neuronal signal transduction

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12 December 2020

Neurotrophin signal transduction in the nervous system

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12 December 2020

Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor

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12 December 2020

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

1 reference

12 December 2020

Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons

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12 December 2020

Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat.

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12 December 2020

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

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12 December 2020

Selection of intracellular antibodies

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12 December 2020

Selective effects of nerve growth factor on spatial recent memory as assessed by a delayed nonmatching-to-position task in the water maze.

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12 December 2020

Alzheimer's disease is a synaptic failure

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12 December 2020

The cholinergic hypothesis of geriatric memory dysfunction

1 reference

12 December 2020

Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits

1 reference

12 December 2020

Neurotrophin signaling through the p75 neurotrophin receptor

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12 December 2020

Neuropathological stageing of Alzheimer-related changes

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12 December 2020

Polymeric immunoglobulin M is secreted by transfectants of non-lymphoid cells in the absence of immunoglobulin J chain.

1 reference

12 December 2020

Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF

1 reference

12 December 2020

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

1 reference

12 December 2020

Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

1 reference

12 December 2020

Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis

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12 December 2020

A critical period in the sensitivity of basal forebrain cholinergic neurones to NGF deprivation

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12 December 2020

Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

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12 December 2020

Regulation of cell survival by secreted proneurotrophins

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12 December 2020

Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy.

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12 December 2020

Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease.

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12 December 2020

Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons

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12 December 2020

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

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12 December 2020

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

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12 December 2020

Expression and structure of the human NGF receptor

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12 December 2020

Muscular dystrophy in adult and aged anti-NGF transgenic mice resembles an inclusion body myopathy

1 reference

12 December 2020

The biological activity of cross-linked beta nerve growth factor protein

1 reference

12 December 2020

The effects of anti-nerve growth factor monoclonal antibodies on developing basal forebrain neurons are transient and reversible

1 reference

12 December 2020

Region-Specific Neurotrophin Imbalances in Alzheimer Disease

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

Cholinergic function and intellectual decline in Alzheimer's disease

1 reference

12 December 2020

Studies on the structure and binding properties of the cysteine-rich domain of rat low affinity nerve growth factor receptor (p75NGFR)

1 reference

12 December 2020

Nerve growth factor-like immunoreactive profiles in the primate basal forebrain and hippocampal formation

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12 December 2020

Modeled structure of the 75-kDa neurotrophin receptor

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12 December 2020

Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice.

1 reference

12 December 2020

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1 reference

12 December 2020

Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease.

1 reference

12 December 2020

Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis.

1 reference

12 December 2020

Ganstigmine and donepezil improve neurodegeneration in AD11 antinerve growth factor transgenic mice

1 reference

12 December 2020

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor.

1 reference

12 December 2020

Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex.

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12 December 2020

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1 reference

12 December 2020

Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group

1 reference

12 December 2020

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.

1 reference

12 December 2020

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1 reference

12 December 2020

Sortilin is essential for proNGF-induced neuronal cell death

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12 December 2020

The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease

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12 December 2020

Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor

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12 December 2020

The interaction of neurotrophins with the p75NTR common neurotrophin receptor: a comprehensive molecular modeling study

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12 December 2020

Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti-nerve-growth-factor mice.

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12 December 2020

The trk proto-oncogene encodes a receptor for nerve growth factor

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12 December 2020

NGF content in the cerebral cortex of non-demented patients with amyloid-plaques and in symptomatic Alzheimer's disease.

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12 December 2020

Delivery of Nerve Growth Factor to the Brain via the Olfactory Pathway.

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12 December 2020

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

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12 December 2020

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

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12 December 2020

Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease.

1 reference

12 December 2020

10.1007/S10571-006-9112-2

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

16944323