Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial. (Q36591835)

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scientific article published on 18 February 2016

Language	Label	Description	Also known as
English	Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial.	scientific article published on 18 February 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26888075%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26888075%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Plasmodium vivax

0 references

0 references

Plasmodium vivax malaria

1 reference

based on heuristic

inferred from title

Gavin C K W Koh

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26888075%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Alejandro Llanos Cuentas

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26888075%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

12

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26888075%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

author name string

Pamela L St Jean

1

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8 March 2020

Zhengyu Xue

2

1 reference

Europe PubMed Central

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8 March 2020

Nick Carter

3

1 reference

Europe PubMed Central

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8 March 2020

Stephan Duparc

5

1 reference

Europe PubMed Central

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8 March 2020

Maxine Taylor

6

1 reference

Europe PubMed Central

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8 March 2020

Claire Beaumont

7

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8 March 2020

Ronnatrai Rueangweerayut

9

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Europe PubMed Central

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8 March 2020

Justin A Green

11

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Europe PubMed Central

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8 March 2020

Srivicha Krudsood

10

1 reference

Europe PubMed Central

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8 March 2020

publication date

18 February 2016

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8 March 2020

Malaria Journal

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26888075%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

15

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26888075%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

97

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26888075%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Exposure-Response Analyses for Tafenoquine after Administration to Patients with Plasmodium vivax Malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

Differential CYP 2D6 metabolism alters primaquine pharmacokinetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

The clinical and public health problem of relapse despite primaquine therapy: case review of repeated relapses of Plasmodium vivax acquired in Papua New Guinea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

Vivax malaria: neglected and not benign

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

9 September 2017

Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

20 September 2018

Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

20 September 2018

The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

20 September 2018

The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

20 September 2018

Primaquine, SN 13272, a new curative agent in vivax malaria; a preliminary report

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4757974

20 September 2018

A Novel Relay Method for Determining Low-Clearance Values

1 reference

https://api.crossref.org/works/10.1186%2FS12936-016-1145-5

21 January 2018

CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/26888075

12 December 2020

based on heuristic

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