Cysteine cathepsins: multifunctional enzymes in cancer (Q36600996)

15 August 2017

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title

Cysteine cathepsins: multifunctional enzymes in cancer (English)

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15 August 2017

1

Mona Mostafa Mohamed

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15 August 2017

Bonnie F Sloane

2

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PubMed ID

16990854

15 August 2017

language of work or name

English

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publication date

1 October 2006

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15 August 2017

Nature Reviews Cancer

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15 August 2017

6

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15 August 2017

10

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15 August 2017

764-775

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https://scigraph.springernature.com/pub.10.1038/nrc1949

15 August 2017

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cites work

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31 March 2020

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Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation

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Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action

31 March 2020

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Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

31 March 2020

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Cathepsin S required for normal MHC class II peptide loading and germinal center development

31 March 2020

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Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling

31 March 2020

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Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.

31 March 2020

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Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors

31 March 2020

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Neuronal loss and brain atrophy in mice lacking cathepsins B and L

31 March 2020

1 reference

Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans

31 March 2020

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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

31 March 2020

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New developments in the genetics and activation of mast cell proteases

31 March 2020

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Thyroid functions of mouse cathepsins B, K, and L.

31 March 2020

1 reference

A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma.

31 March 2020

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Identification of two new exons and multiple transcription start points in the 5'-untranslated region of the human cathepsin-B-encoding gene

31 March 2020

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Transcription of human cathepsin L mRNA species hCATL B from a novel alternative promoter in the first intron of its gene.

31 March 2020

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Identification and characterization of a novel human cathepsin L splice variant

31 March 2020

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Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA.

31 March 2020

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Exploring the role of 5' alternative splicing and of the 3'-untranslated region of cathepsin B mRNA.

31 March 2020

1 reference

Exon 2 of human cathepsin B derives from an Alu element

31 March 2020

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Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency

31 March 2020

1 reference

Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death

31 March 2020

1 reference

Molecular mechanisms of glioma invasiveness: the role of proteases

31 March 2020

1 reference

Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma

31 March 2020

1 reference

Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms

31 March 2020

1 reference

Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization

31 March 2020

1 reference

Human dipeptidyl-peptidase I. Gene characterization, localization, and expression

31 March 2020

1 reference

The biology of the Ets1 proto-oncogene

31 March 2020

1 reference

Crosstalk between cancer cells and bone microenvironment in bone metastasis

31 March 2020

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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

31 March 2020

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Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1

31 March 2020

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Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages.

31 March 2020

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Differentiating agents regulate cathepsin B gene expression in HL-60 cells.

31 March 2020

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Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

31 March 2020

1 reference

A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer

31 March 2020

1 reference

Genomic Analysis Defines a Cancer-Specific Gene Expression Signature for Human Squamous Cell Carcinoma and Distinguishes Malignant Hyperproliferation from Benign Hyperplasia

31 March 2020

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Use of a transgenic mouse model to identify markers of human lung tumors

31 March 2020

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Expression of cathepsins B and S in the progression of prostate carcinoma

31 March 2020

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Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia

31 March 2020

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Molecular characterization of the tumor microenvironment in breast cancer

31 March 2020

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The clinical significance of cathepsin S expression in human astrocytomas.

31 March 2020

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Immunolocalization of cathepsin B in human glioma: implications for tumor invasion and angiogenesis

31 March 2020

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Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues

31 March 2020

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Procathepsin L degrades extracellular matrix proteins in the presence of glycosaminoglycans in vitro

31 March 2020

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Distinct roles for cysteine cathepsin genes in multistage tumorigenesis

31 March 2020

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Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes

31 March 2020

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Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B.

31 March 2020

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The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling

31 March 2020

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Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

31 March 2020

1 reference

Cell-surface cathepsin B: Understanding its functional significance

31 March 2020

1 reference

Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation

31 March 2020

1 reference

MHC class II/CD38/CD9: a lipid-raft-dependent signaling complex in human monocytes

31 March 2020

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B cell signaling is regulated by induced palmitoylation of CD81.

31 March 2020

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Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells

31 March 2020

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Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells

31 March 2020

1 reference

Annexins: from structure to function

31 March 2020

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Annexin II regulates multivesicular endosome biogenesis in the degradation pathway of animal cells

31 March 2020

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Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L.

31 March 2020

1 reference

Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes

31 March 2020

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Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin

31 March 2020

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Cholesteryl ester is transported from caveolae to internal membranes as part of a caveolin-annexin II lipid-protein complex

31 March 2020

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The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae

31 March 2020

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Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.

31 March 2020

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Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases

31 March 2020

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FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth

31 March 2020

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Pericellular cathepsin B and malignant progression

31 March 2020

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Mistargeting of the lectin ERGIC-53 to the endoplasmic reticulum of HeLa cells impairs the secretion of a lysosomal enzyme

31 March 2020

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The lectin ERGIC-53 is a cargo transport receptor for glycoproteins

31 March 2020

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Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer

31 March 2020

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Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells

31 March 2020

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Analysis of a truncated form of cathepsin H in human prostate tumor cells

31 March 2020

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Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages

31 March 2020

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Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages

31 March 2020

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A Lipoxygenase Metabolite, 12-(S)-HETE, Stimulates Protein Kinase C-Mediated Release of Cathepsin B from Malignant Cells

31 March 2020

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IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptor

31 March 2020

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Acid-mediated tumor invasion: a multidisciplinary study

31 March 2020

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Friends or foes - bipolar effects of the tumour stroma in cancer

31 March 2020

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Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells

31 March 2020

1 reference

Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes

31 March 2020

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LIM kinase 1: evidence for a role in the regulation of intracellular vesicle trafficking of lysosomes and endosomes in human breast cancer cells.

31 March 2020

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Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes

31 March 2020

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Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation.

31 March 2020

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Cathepsin X binds to cell surface heparan sulfate proteoglycans

31 March 2020

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Imaging proteolysis by living human breast cancer cells

31 March 2020

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The mannose receptor family

31 March 2020

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Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis

31 March 2020

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Reduction of experimental human fibrosarcoma lung metastasis in mice by adenovirus-mediated cystatin C overexpression in the host

31 March 2020

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Cystatin m: a novel candidate tumor suppressor gene for breast cancer.

31 March 2020

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Overexpression of stefin A in human esophageal squamous cell carcinoma cells inhibits tumor cell growth, angiogenesis, invasion, and metastasis

31 March 2020

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Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion

31 March 2020

1 reference

Cysteine cathepsins in human cancer

31 March 2020

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Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

31 March 2020

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Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

31 March 2020

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Effects of angiogenesis inhibitors on multistage carcinogenesis in mice

31 March 2020

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Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells.

31 March 2020

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Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype

31 March 2020

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Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer

31 March 2020

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Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment

31 March 2020

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Lysosomes and autophagy in cell death control

31 March 2020

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Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis

31 March 2020

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Towards third generation matrix metalloproteinase inhibitors for cancer therapy

31 March 2020

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Cathepsin L is required for endothelial progenitor cell-induced neovascularization

31 March 2020

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Functional imaging of tumor proteolysis

31 March 2020

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Tumor protease-activated, pore-forming toxins from a combinatorial library.

31 March 2020

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Cytotoxic activity of a tumor protease-activated pore-forming toxin

31 March 2020

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Influence of doxorubicin on gene expression and protein pattern in HeLa cells

31 March 2020

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Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470.

31 March 2020

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Polymer conjugates: nanosized medicines for treating cancer

31 March 2020

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Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.

31 March 2020

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RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas.

31 March 2020

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Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site

31 March 2020

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Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice.

31 March 2020

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Inhibitory properties of cystatin F and its localization in U937 promonocyte cells

31 March 2020

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31 March 2020

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Expression of the urokinase-type plasminogen activator receptor in human articular chondrocytes: association with caveolin and beta 1-integrin

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1949

1 reference

PubMed ID

16990854

Dimensions Publication ID

15 August 2017

0 references

1 reference

PubMed ID

16990854