Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf (Q36602394)

15 August 2017

Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf (English)

1 reference

15 August 2017

Caenorhabditis elegans

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1 reference

Masaki Mizunuma

5

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author name string

Takahiro Ogawa

1

1 reference

15 August 2017

Yukihiro Kodera

2

1 reference

15 August 2017

Dai Hirata

3

1 reference

15 August 2017

T Keith Blackwell

4

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15 August 2017

language of work or name

English

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publication date

22 February 2016

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15 August 2017

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15 August 2017

6

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15 August 2017

21611

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Creative Commons Attribution 4.0 International

15 August 2017

start time

22 February 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4761942/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/srep21611

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cites work

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mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

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Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf

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Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance

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TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

30 September 2017

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Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity

30 September 2017

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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

30 September 2017

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Measuring Caenorhabditis elegans life span in 96 well microtiter plates

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Protective effect of sulforaphane against oxidative stress: recent advances

30 September 2017

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RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.

30 September 2017

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Stress-activated cap'n'collar transcription factors in aging and human disease

30 September 2017

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Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.

30 September 2017

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The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans

30 September 2017

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Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

30 September 2017

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Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

30 September 2017

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Two neurons mediate diet-restriction-induced longevity in C. elegans

30 September 2017

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Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways

30 September 2017

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SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response

30 September 2017

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

30 September 2017

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Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent

30 September 2017

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Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide.

30 September 2017

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30 September 2017

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A C. elegans mutant that lives twice as long as wild type

30 September 2017

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Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

30 September 2017

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Effect of garlic (Allium sativum linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol

30 September 2017

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The genetics of Caenorhabditis elegans

30 September 2017

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The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake

30 September 2017

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Antiproliferative effects of garlic constituents in cultured human breast-cancer cells.

30 September 2017

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The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation

30 September 2017

1 reference

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The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response

28 June 2018

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Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons.

28 June 2018

1 reference

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Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.

28 June 2018

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skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo

28 June 2018

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S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo

28 June 2018

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Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.

20 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4761942

Protective effect of s-allyl cysteine and s-propyl cysteine on acetaminophen-induced hepatotoxicity in mice

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4761942

DAF-16 target genes that control C. elegans life-span and metabolism.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4761942

Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4761942

Water-soluble organosulfur compounds of garlic inhibit fatty acid and triglyceride syntheses in cultured rat hepatocytes

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4761942

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4761942

Chemopreventive effect of S-allylcysteine and its relationship to the detoxification enzyme glutathione S-transferase.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4761942

An intervention resembling caloric restriction prolongs life span and retards aging in yeast

20 September 2018

1 reference

12 December 2020

S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway

1 reference

12 December 2020

The Keap1-Nrf2 system as an in vivo sensor for electrophiles

1 reference

12 December 2020

Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury in mice

1 reference

12 December 2020

Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic

1 reference

12 December 2020

The cooperative interaction between vitamin E and vitamin C in suppression of peroxidation of membrane phospholipids

1 reference

12 December 2020

Hypochlorous acid scavenging activities of thioallyl compounds from garlic

1 reference

12 December 2020

Pharmacokinetics of the garlic compound S-allylcysteine

1 reference

12 December 2020

Antihepatotoxic actions of Allium sativum bulbs

1 reference

12 December 2020

Inhibition of cholesterol biosynthesis by organosulfur compounds derived from garlic

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP21611

1 reference

15 August 2017

1 reference

15 August 2017

1 reference