Inactive and active states and supramolecular organization of GPCRs: insights from computational modeling (Q36606981)

15 August 2017

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title

Inactive and active states and supramolecular organization of GPCRs: insights from computational modeling (English)

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G protein-coupled receptor

15 August 2017

main subject

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author name string

Francesca Fanelli

series ordinal

1

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15 August 2017

Pier G De Benedetti

series ordinal

2

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15 August 2017

publication date

1 July 2006

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Journal of Computer - Aided Molecular Design

15 August 2017

published in

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15 August 2017

volume

20

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15 August 2017

issue

7-8

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15 August 2017

page(s)

449-461

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Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.

15 August 2017

cites work

1 reference

12 December 2020

Rhodopsin activation follows precoupling with transducin: inferences from computational analysis

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G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction

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12 December 2020

Prediction of interfaces for oligomerizations of G-protein coupled receptors.

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12 December 2020

G-protein-coupled receptor dimerization: modulation of receptor function.

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12 December 2020

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

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12 December 2020

Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation

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12 December 2020

The DRY motif as a molecular switch of the human oxytocin receptor.

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12 December 2020

The superfamily of heptahelical receptors

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12 December 2020

Insight into mutation-induced activation of the luteinizing hormone receptor: molecular simulations predict the functional behavior of engineered mutants at M398.

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12 December 2020

Theoretical study of the electrostatically driven step of receptor-G protein recognition

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12 December 2020

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

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12 December 2020

Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

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12 December 2020

Seven-transmembrane receptors

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12 December 2020

Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.

1 reference

12 December 2020

X-ray crystallographic studies for ligand-protein interaction changes in rhodopsin

1 reference

12 December 2020

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

1 reference

12 December 2020

Theoretical study on mutation-induced activation of the luteinizing hormone receptor

1 reference

12 December 2020

Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling

1 reference

12 December 2020

Activation of rhodopsin: new insights from structural and biochemical studies

1 reference

12 December 2020

Computational modeling approaches to structure-function analysis of G protein-coupled receptors

1 reference

12 December 2020

Molecular dynamics simulations of m3-muscarinic receptor activation and QSAR analysis

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12 December 2020

Automatic methods for predicting functionally important residues

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12 December 2020

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation

1 reference

12 December 2020

Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation

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12 December 2020

An Implicit Membrane Generalized Born Theory for the Study of Structure, Stability, and Interactions of Membrane Proteins

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12 December 2020

Prediction of MEF2A-DNA interface by rigid body docking: a tool for fast estimation of protein mutational effects on DNA binding.

1 reference

12 December 2020

Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation

1 reference

12 December 2020

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

1 reference

12 December 2020

Computer simulations of signal transduction mechanism in alpha 1B-adrenergic and m3-muscarinic receptors

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12 December 2020

Structural aspects of luteinizing hormone receptor: information from molecular modeling and mutagenesis

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12 December 2020

G-protein-coupled receptor oligomerization and its potential for drug discovery

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12 December 2020

Monomeric G-protein-coupled receptor as a functional unit

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12 December 2020

Entropy and oligomerization in GPCRs

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12 December 2020

Oligomerisation of G-protein-coupled receptors.

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12 December 2020

Activation mechanism of human oxytocin receptor: a combined study of experimental and computer-simulated mutagenesis

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12 December 2020

The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

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12 December 2020

Can allosteric regulation be predicted from structure?

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12 December 2020

Crystal structure of rhodopsin: A G protein-coupled receptor

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12 December 2020

ZDOCK: an initial-stage protein-docking algorithm.

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12 December 2020

Effective energy function for proteins in lipid membranes

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12 December 2020

Oligomerization of G-protein-coupled transmitter receptors.

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12 December 2020

A molecular dissection of the glycoprotein hormone receptors.

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12 December 2020

Pleiotropic effects of substitutions of a highly conserved leucine in transmembrane helix III of the human lutropin/choriogonadotropin receptor with respect to constitutive activation and hormone responsiveness.

1 reference

12 December 2020

The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor

1 reference

12 December 2020

Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices

1 reference

12 December 2020

Molecular dynamics simulations of the ligand-induced chemical information transfer in the 5-HT(1A) receptor.

1 reference

12 December 2020

A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7

1 reference

12 December 2020

Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

1 reference

12 December 2020

Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.

1 reference

12 December 2020

G-protein coupled receptor oligomerization in neuroendocrine pathways

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12 December 2020

The 2.0 A crystal structure of a heterotrimeric G protein

1 reference

12 December 2020

Lutropin receptor function: insights from natural, engineered, and computer-simulated mutations.

1 reference

12 December 2020

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

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12 December 2020

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

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12 December 2020

Oligomerization of G protein-coupled receptors: past, present, and future

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12 December 2020

Roles of G-protein-coupled receptor dimerization

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12 December 2020

The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective

1 reference

12 December 2020

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

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12 December 2020

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

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12 December 2020

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

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12 December 2020

Dimerization in Aminergic G-Protein-Coupled Receptors: Application of a Hidden-Site Class Model of Evolution†

1 reference

12 December 2020

Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function

1 reference

12 December 2020

Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling.

1 reference

12 December 2020

Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.

1 reference

12 December 2020

Molecular tinkering of G protein-coupled receptors: an evolutionary success

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12 December 2020

Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy

1 reference

12 December 2020

Toward the active conformations of rhodopsin and the beta2-adrenergic receptor

1 reference

12 December 2020

High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3.

1 reference

12 December 2020

Efficacy at G-protein-coupled receptors

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12 December 2020

Ab InitioModeling and Molecular Dynamics Simulation of the α1b-Adrenergic Receptor Activation

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12 December 2020

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

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12 December 2020

A novel shape complementarity scoring function for protein‐protein docking

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12 December 2020

Probing rhodopsin-transducin interactions by surface modification and mass spectrometry

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12 December 2020

A GPCR that is not "DRY".

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12 December 2020

Surface plasmon resonance spectroscopy studies of membrane proteins: transducin binding and activation by rhodopsin monitored in thin membrane films

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12 December 2020

The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology

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12 December 2020

The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics.

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12 December 2020

Dimerization of G-protein-coupled receptors.

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12 December 2020

Probing fragment complementation by rigid-body docking: in silico reconstitution of calbindin D9k.

1 reference

12 December 2020

Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotide-binding protein, transducin

1 reference

12 December 2020

Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.

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12 December 2020

Transducin-dependent protonation of glutamic acid 134 in rhodopsin

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12 December 2020

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

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12 December 2020

Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state

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12 December 2020

Agonist efficacy and allosteric models of receptor action.

1 reference

12 December 2020

Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch

1 reference

12 December 2020

Quaternary structure predictions of transmembrane proteins starting from the monomer: a docking-based approach

1 reference

12 December 2020

The lutropin/choriogonadotropin receptor, a 2002 perspective

1 reference

12 December 2020

10.1007/S10822-006-9064-0

Identifiers

DOI

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journals/jcamd/FanelliB06

15 August 2017

DBLP publication ID

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DBLP Dataset 2021-01-02

28 January 2021

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