Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria (Q36608789)

15 August 2017

Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria (English)

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15 August 2017

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4 June 2020

Jessica M Adams

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4 June 2020

Malcolm J Low

7

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4 June 2020

author name string

Brian Fagel

3

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4 June 2020

Daniel D Lam

4

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4 June 2020

Nathan Qi

5

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4 June 2020

Marcelo Rubinstein

6

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4 June 2020

language of work or name

English

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publication date

14 October 2015

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15 August 2017

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4 June 2020

volume

65

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4 June 2020

issue

3

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4 June 2020

page(s)

660-672

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Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

4 June 2020

cites work

1 reference

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Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold

30 September 2017

1 reference

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Somatostatin is essential for the sexual dimorphism of GH secretion, corticosteroid-binding globulin production, and corticosterone levels in mice.

30 September 2017

1 reference

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Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis.

30 September 2017

1 reference

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Cooperation between brain and islet in glucose homeostasis and diabetes

30 September 2017

1 reference

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FGF19 action in the brain induces insulin-independent glucose lowering

30 September 2017

1 reference

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Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons

30 September 2017

1 reference

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Obesity-programmed mice are rescued by early genetic intervention

30 September 2017

1 reference

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Melanocortin-3 receptor regulates the normal fasting response

30 September 2017

1 reference

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Simultaneous measurement of insulin sensitivity, insulin secretion, and the disposition index in conscious unhandled mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study

30 September 2017

1 reference

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Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

The central melanocortin system directly controls peripheral lipid metabolism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Cardiovascular and renal actions of melanocyte-stimulating hormone peptides

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

30 September 2017

1 reference

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Norepinephrine and epinephrine-deficient mice are hyperinsulinemic and have lower blood glucose

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Central melanocortin receptors regulate insulin action

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

30 September 2017

1 reference

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Neural control of renal function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis.

28 June 2018

1 reference

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Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus

20 September 2018

1 reference

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Modulation of blood pressure by central melanocortinergic pathways

20 September 2018

1 reference

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Evaluating the glucose tolerance test in mice

20 September 2018

1 reference

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Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Regulation of blood glucose by hypothalamic pyruvate metabolism

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Sympathetic modulation of the renal glucose transporter GLUT2 in diabetic rats

20 September 2018

1 reference

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Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Altered glucose homeostasis in proopiomelanocortin-null mouse mutants lacking central and peripheral melanocortin

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Hypothalamic insulin signaling is required for inhibition of glucose production

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Renal function and glucose transport in male and female mice with diet-induced type II diabetes mellitus.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

The central melanocortin system can directly regulate serum insulin levels

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Proopiomelanocortin (POMC) products in the central regulation of sympathetic and cardiovascular dynamics: studies on melanocortin and opioid interactions

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764146

Fanconi-Bickel syndrome: GLUT2 mutations associated with a mild phenotype

20 September 2018

1 reference

12 December 2020

In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice

1 reference

12 December 2020

Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion

1 reference

12 December 2020

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

1 reference

12 December 2020

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB15-0804

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26467632%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26467632%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

26467632

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26467632%20AND%20SRC:MED&resulttype=core&format=json