IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor (Q36617062)

15 August 2017

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title

IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor (English)

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granulocyte-macrophage colony-stimulating factor signaling pathway

15 August 2017

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Gene Ontology release 2020-05-02

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James M Murphy

1

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author name string

Ian G Young

series ordinal

2

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15 August 2017

1 January 2006

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15 August 2017

Vitamins and Hormones

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15 August 2017

74

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15 August 2017

1-30

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Three-dimensional structure of a genetically engineered variant of porcine growth hormone

15 August 2017

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A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor

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Structural design and molecular evolution of a cytokine receptor superfamily

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7 January 2021

The immunoglobulin fold. Structural classification, sequence patterns and common core

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7 January 2021

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

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7 January 2021

Crystal structure of a cytokine-binding region of gp130.

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7 January 2021

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

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7 January 2021

Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration

1 reference

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7 January 2021

An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope

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7 January 2021

Granulocyte-macrophage colony-stimulating factor for cancer treatment

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7 January 2021

Structure of an extracellular gp130 cytokine receptor signaling complex

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7 January 2021

A hot spot of binding energy in a hormone-receptor interface

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7 January 2021

The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif

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7 January 2021

Detailed analysis of the IL-5-IL-5R alpha interaction: characterization of crucial residues on the ligand and the receptor.

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7 January 2021

Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction

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7 January 2021

A new cytokine receptor superfamily

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7 January 2021

High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

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7 January 2021

Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

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7 January 2021

Identification of residues involved in binding of IL5 to betacom using betaIL3 and betacom chimeras

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7 January 2021

Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family

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7 January 2021

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

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7 January 2021

Creation of a biologically active interleukin-5 monomer

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7 January 2021

Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.

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7 January 2021

Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3

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7 January 2021

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor

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7 January 2021

Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family

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7 January 2021

Identification of key charged residues of human interleukin-5 in receptor binding and cellular activation.

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7 January 2021

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

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7 January 2021

Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly

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7 January 2021

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor

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7 January 2021

Receptor epitope usage by an interleukin-5 mimetic peptide

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7 January 2021

Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family

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7 January 2021

Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors

1 reference

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7 January 2021

The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling

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7 January 2021

Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5.

1 reference

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7 January 2021

Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.

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7 January 2021

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

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7 January 2021

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

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7 January 2021

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

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7 January 2021

Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

1 reference

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7 January 2021

The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation

1 reference

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7 January 2021

Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex.

1 reference

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7 January 2021

Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family

1 reference

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7 January 2021

Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide

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7 January 2021

A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5

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7 January 2021

Four-helix bundle growth factors and their receptors: protein-protein interactions

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7 January 2021

The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5

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7 January 2021

Molecular cloning and expression of the human interleukin 5 receptor

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7 January 2021

A Novel Functional Epitope Formed by Domains 1 and 4 of the Human Common β-Subunit Is Involved in Receptor Activation by Granulocyte Macrophage Colony-stimulating Factor and Interleukin 5

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7 January 2021

Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains

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7 January 2021

One sequence, two folds: a metastable structure of CD2

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7 January 2021

Ligand-independent cell surface expression of the human soluble granulocyte-macrophage colony-stimulating factor receptor alpha subunit depends on co-expression of the membrane-associated receptor beta subunit

1 reference

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7 January 2021

Roles of the cytoplasmic domains of the alpha and beta subunits of human granulocyte-macrophage colony-stimulating factor receptor.

1 reference

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7 January 2021

The beta subunit of human granulocyte-macrophage colony-stimulating factor receptor forms a homodimer and is activated via association with the alpha subunit

1 reference

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7 January 2021

Saturation mutagenesis of human interleukin-3.

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7 January 2021

Functional replacement of cytokine receptor extracellular domains by leucine zippers

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7 January 2021

Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation

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7 January 2021

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region

1 reference

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7 January 2021

Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognition

1 reference

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7 January 2021

The structure of interleukin-2 complexed with its alpha receptor

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7 January 2021

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation

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7 January 2021

Multimeric cytokine receptors: common versus specific functions

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7 January 2021

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

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7 January 2021

Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation

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7 January 2021

Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding

1 reference

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7 January 2021

Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three recepto

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7 January 2021

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

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7 January 2021

Reconstitution of the functional receptors for murine and human interleukin 5

1 reference

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7 January 2021

A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction

1 reference

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7 January 2021

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1 reference

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7 January 2021

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist

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7 January 2021

Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain

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7 January 2021

A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding

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7 January 2021

JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells.

1 reference

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7 January 2021

The structure, organization, activation and plasticity of the erythropoietin receptor

1 reference

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7 January 2021

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF

1 reference

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7 January 2021

A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr

1 reference

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7 January 2021

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

1 reference

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7 January 2021

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130

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7 January 2021

The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters

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7 January 2021

The hepatic interleukin-6 receptor Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand

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7 January 2021

10.1016/S0083-6729(06)74001-8

Identifiers

DOI

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15 August 2017

1 reference

PubMed ID

17027509