A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells. (Q36625877)

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scientific article published on 16 December 2012

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English	A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.	scientific article published on 16 December 2012

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20 February 2020

A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells (English)

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Michael Andrew Kalwat

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Stephanie M Yoder

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Zhanxiang Wang

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Debbie C Thurmond

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16 December 2012

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Biochemical Pharmacology

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808-816

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Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells

1 reference

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Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo

1 reference

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The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells

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Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

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Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin

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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.

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Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1.

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Lifeact: a versatile marker to visualize F-actin

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An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

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The selectivity of protein kinase inhibitors: a further update

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30 September 2017

Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis

1 reference

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30 September 2017

MEK1 activation by PAK: a novel mechanism

1 reference

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30 September 2017

Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion

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30 September 2017

A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis

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Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans

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Pancreatic Beta-Cell Web: Its Possible Role in Insulin Secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/23246867

12 December 2020

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inferred from PubMed ID database lookup

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23246867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Voltage-gated Ca2+ current in pancreatic B-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23246867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of pancreatic -cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23246867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BCP.2012.12.003

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20 February 2020

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20 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23246867%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

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