Amyloid precursor protein and BACE function as oligomers (Q36626440)

15 August 2017

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title

Amyloid precursor protein and BACE function as oligomers (English)

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15 August 2017

1

Gerd Multhaup

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15 August 2017

1 January 2006

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Neurodegenerative Diseases

15 August 2017

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15 August 2017

3

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15 August 2017

4-5

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15 August 2017

270-274

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It all sticks together--the APP-related family of proteins and Alzheimer's disease

15 August 2017

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Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

21 January 2018

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A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein

21 January 2018

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Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.

21 January 2018

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The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain

21 January 2018

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Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP).

21 January 2018

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Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

21 January 2018

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Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

21 January 2018

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The GxxxG motif: a framework for transmembrane helix-helix association

21 January 2018

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Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies

21 January 2018

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

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Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

21 January 2018

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Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity

21 January 2018

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BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

21 January 2018

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Human BACE forms dimers and colocalizes with APP.

21 January 2018

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Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

21 January 2018

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

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BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

21 January 2018

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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

21 January 2018

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Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000095266

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15 August 2017

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PubMed ID

17047367