Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds (Q36626447)

15 August 2017

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title

Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds (English)

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15 August 2017

Eva Czirr

1

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PubMed ID

17047371

15 August 2017

Sascha Weggen

series ordinal

2

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PubMed ID

17047371

15 August 2017

language of work or name

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1 January 2006

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Neurodegenerative Diseases

15 August 2017

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15 August 2017

3

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15 August 2017

4-5

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15 August 2017

298-304

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Number of dementia sufferers in Europe between the years 2000 and 2050.

15 August 2017

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Alzheimer disease therapy: can the amyloid cascade be halted?

21 January 2018

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Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

21 January 2018

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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Inflammation and Alzheimer's disease

21 January 2018

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Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

21 January 2018

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Selective inhibition of Abeta42 production by NSAID R-enantiomers

21 January 2018

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Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion

21 January 2018

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Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

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Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

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Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

21 January 2018

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Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen

21 January 2018

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The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

21 January 2018

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Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

21 January 2018

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Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

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Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

21 January 2018

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Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

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Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease

21 January 2018

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Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

21 January 2018

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Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures

21 January 2018

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Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action

21 January 2018

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Clinical trial of indomethacin in Alzheimer's disease.

21 January 2018

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The potential role of non-steroidal anti-inflammatory drugs in treating Alzheimer's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000095270

1 reference

15 August 2017

1 reference

PubMed ID

17047371