Alzheimer disease therapy: can the amyloid cascade be halted? (Q34828328)

4 August 2017

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title

Alzheimer disease therapy: can the amyloid cascade be halted? (English)

1 reference

4 August 2017

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Todd E Golde

1

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PubMed ID

12511580

4 August 2017

language of work or name

English

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publication date

1 January 2003

1 reference

Journal of Clinical Investigation

4 August 2017

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4 August 2017

111

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4 August 2017

11-18

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4 August 2017

1

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Open peer commentary regarding Abeta immunization and CNS inflammation by Pasinetti et al.

4 August 2017

1 reference

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Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning

8 July 2018

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Imaging amyloid-beta deposits in vivo

8 July 2018

1 reference

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Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3

8 July 2018

1 reference

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Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia

8 July 2018

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Biological markers and the treatment of Alzheimer's disease

8 July 2018

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Rates of global and regional cerebral atrophy in AD and frontotemporal dementia.

8 July 2018

1 reference

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

8 July 2018

1 reference

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A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

8 July 2018

1 reference

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Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

8 July 2018

1 reference

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

8 July 2018

1 reference

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

8 July 2018

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Prevalence, costs, and treatment of Alzheimer's disease and related dementia: a managed care perspective.

8 July 2018

1 reference

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Alzheimer's disease and Abeta toxicity: from top to bottom

8 July 2018

1 reference

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

8 July 2018

1 reference

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

8 July 2018

1 reference

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Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

8 July 2018

1 reference

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Presenilins as therapeutic targets for the treatment of Alzheimer's disease

8 July 2018

1 reference

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A fluid connection: cholesterol and Abeta

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Alzheimer's disease: genes, proteins, and therapy

8 July 2018

1 reference

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Statins and the risk of dementia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Diagnostic approaches to Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Inflammation and Alzheimer's disease

8 July 2018

1 reference

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A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred

8 July 2018

1 reference

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Intraneuronal Abeta42 accumulation in human brain.

8 July 2018

1 reference

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Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

A stop-codon mutation in the BRI gene associated with familial British dementia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

8 July 2018

1 reference

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Alzheimer's disease: genetic studies and transgenic models

8 July 2018

1 reference

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The role of A beta 42 in Alzheimer's disease

8 July 2018

1 reference

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

8 July 2018

1 reference

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

8 July 2018

1 reference

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

8 July 2018

1 reference

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151845

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

8 July 2018

1 reference

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Mutant genes in familial Alzheimer's disease and transgenic models

8 July 2018

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Apolipoprotein E, a gene with complex biological interactions in the aging brain

8 July 2018

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Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society

8 July 2018

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Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.

8 July 2018

1 reference

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Amyloid, the presenilins and Alzheimer's disease

8 July 2018

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Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

8 July 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

8 July 2018

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Mechanisms of neuronal degeneration in Alzheimer's disease

8 July 2018

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

8 July 2018

1 reference

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

8 July 2018

1 reference

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Alzheimer's disease: the amyloid cascade hypothesis

8 July 2018

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Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain

8 July 2018

1 reference

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The disordered neuronal cytoskeleton in Alzheimer's disease

8 July 2018

1 reference

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Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.

8 July 2018

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Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

26 October 2018

1 reference

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Health care utilization and costs of Alzheimer's disease: the role of co-morbid conditions, disease stage, and pharmacotherapy.

26 October 2018

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Neurodegenerative disease: amyloid pores from pathogenic mutations.

26 October 2018

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Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide.

26 October 2018

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Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.

26 October 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

26 October 2018

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Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease.

26 October 2018

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

26 October 2018

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Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images.

26 October 2018

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Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

26 October 2018

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

26 October 2018

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Cerebrospinal fluid abeta42, tau, and f2-isoprostane concentrations in patients with Alzheimer disease, other dementias, and in age-matched controls

26 October 2018

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Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome.

26 October 2018

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Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.

26 October 2018

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Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice.

26 October 2018

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

26 October 2018

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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

26 October 2018

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Susceptibility locus for Alzheimer's disease on chromosome 10.

26 October 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

26 October 2018

1 reference

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Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

26 October 2018

1 reference

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In vivo reversal of amyloid-beta lesions in rat brain.

26 October 2018

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A full genome scan for late onset Alzheimer's disease.

26 October 2018

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A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

26 October 2018

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Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

26 October 2018

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Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

26 October 2018

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Alzheimer's disease in the NAS-NRC registry of aging twin veterans. II. Longitudinal findings in a pilot series. National Academy of Sciences. National Research Council Registry

26 October 2018

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The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

26 October 2018

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Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

26 October 2018

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12 December 2020

Gamma -secretase inhibitors repress thymocyte development

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12 December 2020

Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity

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12 December 2020

Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees

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12 December 2020

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

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12 December 2020

The genetics of Alzheimer's disease

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12 December 2020

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study

1 reference

12 December 2020

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

1 reference

12 December 2020

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

1 reference

12 December 2020

Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI200317527

1 reference

4 August 2017

1 reference

4 August 2017

1 reference

PubMed ID

12511580