Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance (Q36626452)

15 August 2017

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title

Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance (English)

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15 August 2017

1

Tobias Hartmann

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15 August 2017

1 January 2006

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Neurodegenerative Diseases

15 August 2017

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15 August 2017

3

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15 August 2017

4-5

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15 August 2017

305-311

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

15 August 2017

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

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The amyloid-beta precursor protein: integrating structure with biological function

21 January 2018

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Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

21 January 2018

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Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

21 January 2018

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Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

21 January 2018

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Alzheimer's disease: the cholesterol connection

21 January 2018

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Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

21 January 2018

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Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease.

21 January 2018

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

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Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol.

21 January 2018

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Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

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Spatial segregation of gamma-secretase and substrates in distinct membrane domains

21 January 2018

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

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Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))

21 January 2018

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Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

21 January 2018

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

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Functional rafts in cell membranes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000095271

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15 August 2017

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PubMed ID

17047372