A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia (Q36650564)

15 August 2017

A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia (English)

1 reference

15 August 2017

Karolin V Dorn

1

1 reference

15 August 2017

Casey E Hughes

series ordinal

2

1 reference

15 August 2017

Rajat Rohatgi

series ordinal

3

1 reference

15 August 2017

language of work or name

English

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publication date

13 September 2012

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15 August 2017

13

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inferred from page(s)

published in

Developmental Cell

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15 August 2017

23

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15 August 2017

4

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15 August 2017

823-835

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describes a project that uses

15 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3586260/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Oxysterols are allosteric activators of the oncoprotein Smoothened

30 September 2017

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A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

30 September 2017

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Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

30 September 2017

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30 September 2017

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A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

30 September 2017

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MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

30 September 2017

1 reference

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Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus

30 September 2017

1 reference

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CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content.

30 September 2017

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The primary cilium: a signalling centre during vertebrate development

30 September 2017

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The primary cilium as a Hedgehog signal transduction machine

30 September 2017

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

30 September 2017

1 reference

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Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

30 September 2017

1 reference

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Ellis-van Creveld syndrome and Weyers acrodental dysostosis are caused by cilia-mediated diminished response to hedgehog ligands

30 September 2017

1 reference

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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

30 September 2017

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Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

30 September 2017

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Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia

30 September 2017

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Patched1 regulates hedgehog signaling at the primary cilium

30 September 2017

1 reference

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The graded response to Sonic Hedgehog depends on cilia architecture

30 September 2017

1 reference

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

30 September 2017

1 reference

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

30 September 2017

1 reference

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Vertebrate Smoothened functions at the primary cilium

30 September 2017

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Hedgehog signalling in the mouse requires intraflagellar transport proteins

30 September 2017

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Mutations in two nonhomologous genes in a head-to-head configuration cause Ellis-van Creveld syndrome

30 September 2017

1 reference

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Small molecule modulation of Smoothened activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586260

Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism

30 September 2017

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Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

30 September 2017

1 reference

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Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis

30 September 2017

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Activating Smoothened mutations in sporadic basal-cell carcinoma

30 September 2017

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A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

30 September 2017

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A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes

30 September 2017

1 reference

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Widening the mutation spectrum of EVC and EVC2: ectopic expression of Weyer variants in NIH 3T3 fibroblasts disrupts Hedgehog signaling.

28 June 2018

1 reference

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Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells

28 June 2018

1 reference

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Long interspersed nuclear element-1 (LINE1)-mediated deletion of EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with borderline intelligence.

28 June 2018

1 reference

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The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586260

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3586260

A new gene, EVC2, is mutated in Ellis-van Creveld syndrome

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22981989

12 December 2020

inferred from PubMed ID database lookup

Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22981989

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.DEVCEL.2012.07.004

1 reference

15 August 2017

1 reference

15 August 2017

PubMed publication ID

22981989

1 reference