Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas (Q36652782)

15 August 2017

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title

Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas (English)

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15 August 2017

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Patricia L M Dahia

1

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PubMed ID

17102089

15 August 2017

Familial Pheochromocytoma Consortium

series ordinal

2

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PubMed ID

17102089

15 August 2017

language of work or name

English

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publication date

1 August 2006

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Annals of the New York Academy of Sciences

15 August 2017

13

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based on heuristic

inferred from page(s)

published in

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15 August 2017

1073

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15 August 2017

208-220

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Germ-line mutations in nonsyndromic pheochromocytoma

15 August 2017

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

How oxygen makes its presence felt

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

HIF-1 and tumor progression: pathophysiology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Oxygen sensors and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Mitochondrial tumour suppressors: a genetic and biochemical update

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Direct evidence for expression of type II flavoprotein subunit in human complex II (succinate-ubiquinone reductase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Promoter analysis of the human succinate dehydrogenase iron-protein gene--both nuclear respiratory factors NRF-1 and NRF-2 are required

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Hypoxia requires notch signaling to maintain the undifferentiated cell state

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Malignant pheochromocytoma: current status and initiatives for future progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

21 January 2018

Identifiers

DOI

10.1196/ANNALS.1353.023

1 reference

15 August 2017

1 reference

PubMed ID

17102089