Structural determinants of T-cell receptor bias in immunity (Q36655911)

15 August 2017

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title

Structural determinants of T-cell receptor bias in immunity (English)

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15 August 2017

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15 August 2017

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15 August 2017

Stephen J Turner

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publication date

17 November 2006

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Nature Reviews Immunology

15 August 2017

published in

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15 August 2017

volume

6

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15 August 2017

issue

12

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15 August 2017

page(s)

883-894

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IMGT, the international ImMunoGeneTics database

15 August 2017

cites work

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The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments

21 January 2018

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Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase

21 January 2018

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CDR3 length in antigen-specific immune receptors

21 January 2018

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

21 January 2018

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An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

21 January 2018

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A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

21 January 2018

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A structural basis for immunodominant human T cell receptor recognition

21 January 2018

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The crystal structure of a T cell receptor in complex with peptide and MHC class II

21 January 2018

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Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

21 January 2018

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T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

21 January 2018

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A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

21 January 2018

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Crystal structure of a T cell receptor bound to an allogeneic MHC molecule

21 January 2018

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A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex

21 January 2018

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Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice

21 January 2018

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Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense

21 January 2018

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The structure of H-2K(b) and K(bm8) complexed to a herpes simplex virus determinant: evidence for a conformational switch that governs T cell repertoire selection and viral resistance

21 January 2018

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T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection

21 January 2018

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Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.

21 January 2018

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Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes

21 January 2018

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The many important facets of T-cell repertoire diversity

21 January 2018

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Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

21 January 2018

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Preferential usage of V alpha 4 and V beta 10 T cell receptor genes by lymphocytic choriomeningitis virus glycoprotein-specific H-2Db-restricted cytotoxic T cells

21 January 2018

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Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus.

21 January 2018

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Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction

21 January 2018

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H-2-restricted cytolytic T lymphocytes specific for HLA display T cell receptors of limited diversity

21 January 2018

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T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire

21 January 2018

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T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo

21 January 2018

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Large clonal expansions of CD8+ T cells in acute infectious mononucleosis

21 January 2018

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Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant

21 January 2018

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Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope

21 January 2018

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Contemporary analysis of MHC-related immunodominance hierarchies in the CD8+ T cell response to influenza A viruses

21 January 2018

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Antigen-specific development of primary and memory T cells in vivo.

21 January 2018

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Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

21 January 2018

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Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV.

21 January 2018

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Immune response to the immunodominant epitope of mouse hepatitis virus is polyclonal, but functionally monospecific in C57Bl/6 mice.

21 January 2018

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Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

21 January 2018

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A dominant V beta bias in the CTL response after HSV-1 infection is determined by peptide residues predicted to also interact with the TCR beta-chain CDR3.

21 January 2018

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Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide

21 January 2018

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Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment

21 January 2018

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Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice

21 January 2018

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Control of TCR V alpha-mediated positive repertoire selection and alloreactivity by differential J alpha usage and CDR3 alpha composition

21 January 2018

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Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific.

21 January 2018

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Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses

21 January 2018

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Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes

21 January 2018

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A direct estimate of the human alphabeta T cell receptor diversity

21 January 2018

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How the T Cell Repertoire Becomes Peptide and MHC Specific

21 January 2018

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Control of MHC restriction by TCR Valpha CDR1 and CDR2

21 January 2018

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Preferential expression of TCR V alpha regions in CD4/CD8 subsets: class discrimination or co-receptor recognition?

21 January 2018

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Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences.

21 January 2018

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The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

21 January 2018

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Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction

21 January 2018

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Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses

21 January 2018

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Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface

21 January 2018

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Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.

21 January 2018

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Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs

21 January 2018

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T cell affinity maturation by selective expansion during infection

21 January 2018

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In vivo selection of a TCR Vbeta repertoire directed against an immunodominant influenza virus CTL epitope

21 January 2018

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Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection

21 January 2018

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Analysis of clonotype distribution and persistence for an influenza virus-specific CD8+ T cell response

21 January 2018

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Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones.

21 January 2018

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Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice

21 January 2018

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Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection

21 January 2018

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

21 January 2018

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Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1.

21 January 2018

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Valpha and Vbeta public repertoires are highly conserved in terminal deoxynucleotidyl transferase-deficient mice.

21 January 2018

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An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease

21 January 2018

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T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen

21 January 2018

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Cross-reactive memory T cells for Epstein-Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex-bound peptide by T cells and its role in alloreactivity

21 January 2018

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The diversity of antigen-specific TCR repertoires reflects the relative complexity of epitopes recognized

21 January 2018

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A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

21 January 2018

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Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

21 January 2018

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The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

21 January 2018

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A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge

21 January 2018

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Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance

21 January 2018

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Eight-plasmid system for rapid generation of influenza virus vaccines

21 January 2018

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High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance

21 January 2018

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Phenotypic analysis of antigen-specific T lymphocytes

21 January 2018

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The outline structure of the T-cell alpha beta receptor.

21 January 2018

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Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR

31 March 2020

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Longitudinal analysis of T cells responding to tetanus toxoid in healthy subjects as well as in pediatric patients after bone marrow transplantation: the identification of identical TCR-CDR3 regions in time suggests long-term stability of at least p

31 March 2020

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Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires

31 March 2020

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The Shaping of the T Cell Repertoire

31 March 2020

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Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes

31 March 2020

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T cell fitness determined by signal strength

31 March 2020

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Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

31 March 2020

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Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties

31 March 2020

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The TCR repertoire of an immunodominant CD8+ T lymphocyte population

31 March 2020

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Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer

31 March 2020

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Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias

31 March 2020

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7 January 2021

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Identifiers

DOI

10.1038/NRI1977

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15 August 2017

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