Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology (Q36662875)

15 August 2017

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title

Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology (English)

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15 August 2017

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John Cl Erve

1

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15 August 2017

language of work or name

English

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publication date

1 December 2006

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Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

published in

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15 August 2017

volume

2

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15 August 2017

issue

6

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15 August 2017

page(s)

923-946

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The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

A comprehensive listing of bioactivation pathways of organic functional groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Overview of drug-protein binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Protein targets of xenobiotic reactive intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

The role of metabolic activation in drug-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Identification of seven proteins in the endoplasmic reticulum as targets for reactive metabolites of bromobenzene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Proteomic characterization of metabolites, protein adducts, and biliary proteins in rats exposed to 1,1-dichloroethylene or diclofenac

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Safety issues surrounding the use of aromatase inhibitors in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Aromatase inhibitors in breast cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Novel aromatase and 5 alpha-reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Exemestane, a new steroidal aromatase inhibitor of clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

The therapeutic potential of aromatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Neutrophil elastase inhibitors as treatment for COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Emerging drugs for the treatment of chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

The organ toxicity of inhaled anesthetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Mechanisms of halothane toxicity: novel insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Mechanisms of actions of inhaled anesthetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Anesthesiology. First of two parts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Hepatotoxicity after desflurane anesthesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Phagocyte-mediated oxidation in idiosyncratic adverse drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Clopidogrel-associated TTP: an update of pharmacovigilance efforts conducted by independent researchers, pharmaceutical suppliers, and the Food and Drug Administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Thrombotic thrombocytopenic purpura associated with clopidogrel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Mechanistic perspectives on sulfonamide-induced cutaneous drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Drug metabolism in the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Do arylhydroxylamine metabolites mediate idiosyncratic reactions associated with sulfonamides?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Anticonvulsant hypersensitivity syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Antiepileptic drug hypersensitivity syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide. An update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Mechanisms of idiosyncratic drug reactions: the case of felbamate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Synthesis and in vitro reactivity of 3-carbamoyl-2-phenylpropionaldehyde and 2-phenylpropenal: putative reactive metabolites of felbamate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Investigating the role of 2-phenylpropenal in felbamate-induced idiosyncratic drug reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Reye-like syndrome associated with valproic acid therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-n-propyl-4-pentenoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: hepatic microvesicular steatosis and glutathione status

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Inhibition of tubulin assembly and covalent binding to microtubular protein by valproic acid glucuronide in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Protection of dopaminergic neurons with a novel astrocyte modulating agent (R)-(-)-2-propyloctanoic acid (ONO-2506) in an MPTP-mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Stability and comparative metabolism of selected felbamate metabolites and postulated fluorofelbamate metabolites by postmitochondrial suspensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Drug therapy for alcohol dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Expression of autoantibodies to specific cytochromes P450 in a case of disulfiram hepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Determination of in vivo adducts of disulfiram with mitochondrial aldehyde dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Disulfiram produces a non-carbon disulfide-dependent schwannopathy in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Two-dimensional database of mouse liver proteins: changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Caspase-dependent and -independent mechanisms in apoptosis induced by hydroquinone and catechol metabolites of remoxipride in HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Induction of apoptosis by remoxipride metabolites in HL60 and CD34+/CD19- human bone marrow progenitor cells: potential relevance to remoxipride-induced aplastic anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Characterization of glutathione conjugates of the remoxipride hydroquinone metabolite NCQ-344 formed in vitro and detection following oxidation by human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

The discovery of epidepride and its analogs as high-affinity radioligands for imaging extrastriatal dopamine D(2) receptors in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Comparative toxicological study on the hepatic safety of entacapone and tolcapone in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Entacapone, a novel catechol-O-methyltransferase inhibitor for Parkinson's disease, does not impair mitochondrial energy production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Effects of entacapone and tolcapone on mitochondrial membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Massive plasmocytosis due to methimazole-induced bone marrow toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Methimazole toxicity in rodents: covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

Synthesis of a prodrug designed to release multiple inhibitors of the epidermal growth factor receptor tyrosine kinase and an alkylating agent: a novel tumor targeting concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.923

21 January 2018

Identifiers

DOI

10.1517/17425255.2.6.923

1 reference

15 August 2017

1 reference