The role of large-scale motions in catalysis by dihydrofolate reductase. (Q36664384)

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16 January 2020

title

The role of large-scale motions in catalysis by dihydrofolate reductase (English)

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16 January 2020

1

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16 January 2020

William M Dawson

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16 January 2020

Rhiannon M Evans

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16 January 2020

Christopher Williams

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16 January 2020

Matthew P. Crump

9

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2

Lai-Hock Tey

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3

Enas M Behiry

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16 January 2020

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Rudolf K Allemann

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16 January 2020

author name string

Sara B-M Whittaker

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16 January 2020

Ulrich L Günther

7

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16 January 2020

language of work or name

English

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publication date

22 November 2011

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Journal of the American Chemical Society

16 January 2020

published in

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volume

133

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issue

50

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page(s)

20561-20570

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Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

16 January 2020

cites work

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Slow conformational motions that favor sub-picosecond motions important for catalysis

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30 September 2017

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Protein dynamics and stability: the distribution of atomic fluctuations in thermophilic and mesophilic dihydrofolate reductase derived using elastic incoherent neutron scattering

30 September 2017

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Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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Effect of pH on hydride transfer by Escherichia coli dihydrofolate reductase.

28 June 2018

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Catalysis by dihydrofolate reductase from the psychropiezophile Moritella profunda.

20 September 2018

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The temperature dependence of the kinetic isotope effects of dihydrofolate reductase from Thermotoga maritima is influenced by intersubunit interactions

20 September 2018

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The role of arginine 28 in catalysis by dihydrofolate reductase from the hyperthermophile Thermotoga maritima

20 September 2018

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Effect of dimerization on the stability and catalytic activity of dihydrofolate reductase from the hyperthermophile Thermotoga maritima.

20 September 2018

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Different reaction mechanisms for mesophilic and thermophilic dihydrofolate reductases

20 September 2018

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Solvent effects on environmentally coupled hydrogen tunnelling during catalysis by dihydrofolate reductase from Thermotoga maritima

20 September 2018

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Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions

20 September 2018

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Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase

20 September 2018

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The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies

20 September 2018

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Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase

20 September 2018

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How enzyme dynamics helps catalyze a reaction in atomic detail: a transition path sampling study

20 September 2018

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High pressure nmr study of dihydrofolate reductase from a deep-sea bacterium Moritella profunda

20 September 2018

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Pivotal role of Gly 121 in dihydrofolate reductase from Escherichia coli: the altered structure of a mutant enzyme may form the basis of its diminished catalytic performance

20 September 2018

1 reference

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Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis

20 September 2018

1 reference

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Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes

20 September 2018

1 reference

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Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima

20 September 2018

1 reference

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Are Environmentally Coupled Enzymatic Hydrogen Tunneling Reactions Influenced by Changes in Solution Viscosity?

20 September 2018

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Very Fast Two-Dimensional NMR Spectroscopy for Real-Time Investigation of Dynamic Events in Proteins on the Time Scale of Seconds

4 December 2018

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Modeling hydration mechanisms of enzymes in nonpolar and polar organic solvents

4 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22060818

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Microsecond subdomain folding in dihydrofolate reductase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22060818

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Viscosity dependence of protein dynamics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22060818

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JA208844J

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22060818%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22060818%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

22060818

1 reference