Choline metabolism in cancer: implications for diagnosis and therapy (Q36670926)

15 August 2017

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title

Choline metabolism in cancer: implications for diagnosis and therapy (English)

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15 August 2017

Kristine Glunde

1

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PubMed ID

17140369

15 August 2017

Michael A Jacobs

series ordinal

2

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PubMed ID

17140369

15 August 2017

Zaver M Bhujwalla

series ordinal

3

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15 August 2017

1 November 2006

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

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9

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published in

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15 August 2017

6

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821-829

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Imaging biochemistry: applications to breast cancer

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Choline phospholipid metabolism: a target in cancer cells?

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Alterations of choline phospholipid metabolism in ovarian tumor progression

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Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS.

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Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions

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Volume localized in vivo proton MR spectroscopy of breast carcinoma: variation of water-fat ratio in patients receiving chemotherapy

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Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study

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Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions

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In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI.

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Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: a feasibility study

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The role of fluorodeoxyglucose, 18F-dihydroxyphenylalanine, 18F-choline, and 18F-fluoride in bone imaging with emphasis on prostate and breast

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An improved 1H magnetic resonance spectroscopic imaging technique for the human breast: preliminary results

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Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy

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Clinical value of proton magnetic resonance spectroscopy for differentiating recurrent or residual brain tumor from delayed cerebral necrosis.

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Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy.

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Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer

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Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer

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Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging.

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Quantification of phosphocholine and glycerophosphocholine with 31P edited 1H NMR spectroscopy

21 January 2018

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Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters

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Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy

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1H and 13C HR-MAS spectroscopy of intact biopsy samples ex vivo and in vivo 1H MRS study of human high grade gliomas

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Molecular imaging of cancer with positron emission tomography

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Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells

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Exposure of human breast cancer cells to the anti-inflammatory agent indomethacin alters choline phospholipid metabolites and Nm23 expression

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Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I.

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Molecular causes of the aberrant choline phospholipid metabolism in breast cancer

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Intracellular signaling by phospholipase D as a therapeutic target

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Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers

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Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy

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RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation

21 January 2018

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Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines

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Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.

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Choline kinase inhibitors as a novel approach for antiproliferative drug design

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Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells.

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Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models

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High-resolution magic angle spinning MRS of breast cancer tissue

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21 January 2018

Identifiers

DOI

10.1586/14737159.6.6.821

1 reference

15 August 2017

1 reference

PubMed ID

17140369