ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons. (Q36678823)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26905200%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons (English)

1 reference

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8 March 2020

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Hugo J Ribeiro Fernandes

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Helen Christian

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Brent J Ryan

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George K Tofaris

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Kevin Talbot

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Michele T M Hu

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William James

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Sally A. Cowley

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Richard Wade-Martins

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author name string

Elizabeth M Hartfield

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Evangelia Emmanoulidou

4

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Ying Zheng

5

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Heather Booth

6

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Helle Bogetofte

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Charmaine Lang

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S Pablo Sardi

10

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Jennifer Badger

11

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Jane Vowles

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Samuel Evetts

13

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Kostas Vekrellis

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18 February 2016

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volume

6

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issue

3

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8 March 2020

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342-356

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describes a project that uses

8 March 2020

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Identification of distinct circulating exosomes in Parkinson's disease

1 reference

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The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity

30 September 2017

1 reference

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1 reference

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Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

30 September 2017

1 reference

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30 September 2017

1 reference

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Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.

30 September 2017

1 reference

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Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis

30 September 2017

1 reference

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Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion

30 September 2017

1 reference

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30 September 2017

1 reference

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Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

30 September 2017

1 reference

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Cellular reprogramming: a new approach to modelling Parkinson's disease.

30 September 2017

1 reference

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Guidelines for the use and interpretation of assays for monitoring autophagy

30 September 2017

1 reference

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Lysosome-dependent pathways as a unifying theme in Parkinson's disease.

30 September 2017

1 reference

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway

30 September 2017

1 reference

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Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential

30 September 2017

1 reference

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Assessment of α-synuclein secretion in mouse and human brain parenchyma

30 September 2017

1 reference

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Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease

30 September 2017

1 reference

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CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

30 September 2017

1 reference

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

30 September 2017

1 reference

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A bioinformatic assay for pluripotency in human cells

30 September 2017

1 reference

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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

X-ray and biochemical analysis of N370S mutant human acid β-glucosidase.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Pathogenic lysosomal depletion in Parkinson's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

30 September 2017

1 reference

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Altered lipid content inhibits autophagic vesicular fusion

30 September 2017

1 reference

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30 September 2017

1 reference

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Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

30 September 2017

1 reference

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30 September 2017

1 reference

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Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.

30 September 2017

1 reference

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Endoplasmic reticulum stress triggers autophagy

30 September 2017

1 reference

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

30 September 2017

1 reference

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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

30 September 2017

1 reference

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Parkinsonism among Gaucher disease carriers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

30 September 2017

1 reference

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30 September 2017

1 reference

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28 June 2018

1 reference

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iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Activity-dependent secretion of alpha-synuclein by enteric neurons

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Parkinson patient fibroblasts show increased alpha-synuclein expression

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Glucocerebrosidase mutations are an important risk factor for Lewy body disorders.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

Association of mutations in the glucocerebrosidase gene with Parkinson disease in a Korean population

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4788783

10.1016/J.STEMCR.2016.01.013

4 December 2018

Identifiers

DOI

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release_holgp6b2zzb4ngcaio25babcdy

8 March 2020

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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8 March 2020

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