BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition (Q36684951)

15 August 2017

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition (English)

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15 August 2017

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4

Leandro Cerchietti

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Markus Müschen

23

object named as

Markus Müschen

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Thomas Graeber

object named as

Thomas G Graeber

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author name string

Cihangir Duy

1

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15 August 2017

Christian Hurtz

2

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15 August 2017

Seyedmehdi Shojaee

3

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15 August 2017

Huimin Geng

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15 August 2017

Srividya Swaminathan

6

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15 August 2017

Lars Klemm

7

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15 August 2017

Soo-mi Kweon

8

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15 August 2017

Rahul Nahar

9

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15 August 2017

Melanie Braig

10

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15 August 2017

Eugene Park

11

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15 August 2017

Yong-mi Kim

12

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15 August 2017

Wolf-Karsten Hofmann

13

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15 August 2017

Sebastian Herzog

14

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15 August 2017

Hassan Jumaa

15

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15 August 2017

H Phillip Koeffler

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15 August 2017

J Jessica Yu

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15 August 2017

Nora Heisterkamp

18

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15 August 2017

Hong Wu

20

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15 August 2017

B Hilda Ye

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15 August 2017

Ari Melnick

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15 August 2017

Markus Müschen

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15 August 2017

language of work or name

English

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publication date

1 May 2011

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15 August 2017

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15 August 2017

473

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15 August 2017

384-388

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15 August 2017

7347

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https://scigraph.springernature.com/pub.10.1038/nature09883

15 August 2017

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cites work

Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

BCL6 is critical for the development of a diverse primary B cell repertoire

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Loss of p53 impedes the antileukemic response to BCR-ABL inhibition

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Treatment of chronic myeloid leukemia cells with imatinib (STI571) impairs p53 accumulation in response to DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Overriding imatinib resistance with a novel ABL kinase inhibitor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Imatinib mesylate induces cisplatin hypersensitivity in Bcr-Abl+ cells by differential modulation of p53 transcriptional and proapoptotic activity

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Oncogene-induced senescence as an initial barrier in lymphoma development

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597744

Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation

5 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Dicer1 functions as a haploinsufficient tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

A transient three-plasmid expression system for the production of high titer retroviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

Treatment of Chronic Myeloid Leukemia Cells with Imatinib (STI571) Impairs p53 Accumulation in Response to DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09883

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE09883

1 reference

15 August 2017

1 reference

15 August 2017

1 reference