Experience and challenges from clinical trials with malaria vaccines in Africa (Q36690983)

15 August 2017

6 references

23 March 2019

20 June 2019

22 June 2019

19 September 2019

8 September 2020

14 January 2024

Experience and challenges from clinical trials with malaria vaccines in Africa (English)

1 reference

biomedical investigative technique

15 August 2017

5 references

23 March 2019

20 June 2019

22 June 2019

19 September 2019

8 September 2020

1 reference

19 September 2019

1 reference

8 September 2020

1 reference

9

Marcel Tanner

1 reference

15 August 2017

2

Bernhards Ogutu

1 reference

15 August 2017

10

Salim Abdulla

1 reference

15 August 2017

Grace Mwangoka

1

1 reference

15 August 2017

Beverly Msambichaka

3

1 reference

15 August 2017

Tutu Mzee

4

1 reference

15 August 2017

Nahya Salim

5

1 reference

15 August 2017

Shubis Kafuruki

6

1 reference

15 August 2017

Maxmillian Mpina

7

1 reference

15 August 2017

Seif Shekalaghe

8

1 reference

15 August 2017

language of work or name

1 reference

4 March 2013

7 references

15 August 2017

23 March 2019

20 June 2019

22 June 2019

19 September 2019

8 September 2020

14 January 2024

7 references

15 August 2017

23 March 2019

20 June 2019

22 June 2019

19 September 2019

8 September 2020

14 January 2024

12

1 reference

15 August 2017

86

1 reference

Creative Commons Attribution 2.0 Generic

15 August 2017

6 references

23 March 2019

20 June 2019

22 June 2019

19 September 2019

8 September 2020

on focus list of Wikimedia project

14 January 2024

copyright status

copyrighted

0 references

ScienceSource

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/1475-2875-12-86

0 references

cites work

A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E

1 reference

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A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

30 September 2017

1 reference

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A review of malaria vaccine clinical projects based on the WHO rainbow table

30 September 2017

1 reference

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Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Development of standardized laboratory methods and quality processes for a phase III study of the RTS, S/AS01 candidate malaria vaccine

30 September 2017

1 reference

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Virosome-formulated Plasmodium falciparum AMA-1 & CSP derived peptides as malaria vaccine: randomized phase 1b trial in semi-immune adults & children

30 September 2017

1 reference

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Safety and efficacy of the RTS, S/AS01 E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial

30 September 2017

1 reference

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A research agenda for malaria eradication: vaccines

30 September 2017

1 reference

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A Research Agenda to Underpin Malaria Eradication

30 September 2017

1 reference

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Operational strategies to achieve and maintain malaria elimination

30 September 2017

1 reference

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Clinical research in resource-limited settings: enhancing research capacity and working together to make trials less complicated

30 September 2017

1 reference

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The RTS,S malaria vaccine

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Engaging diverse communities participating in clinical trials: case examples from across Africa

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Malaria in pregnancy and the newborn

30 September 2017

1 reference

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Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria

30 September 2017

1 reference

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Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection

30 September 2017

1 reference

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Challenges of establishing a Community Advisory Board (CAB) in a low-income, low-resource setting: experiences from Bagamoyo, Tanzania

30 September 2017

1 reference

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Insights into long-lasting protection induced by RTS,S/AS02A malaria vaccine: further results from a phase IIb trial in Mozambican children

30 September 2017

1 reference

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Estimates of the burden of malaria morbidity in Africa in children under the age of 5 years

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Contribution of influenza immunity and virosomal-formulated synthetic peptide to cellular immune responses in a phase I subunit malaria vaccine trial

30 September 2017

1 reference

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Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Humoral responses to plasmodium falciparum blood-stage antigens and association with incidence of clinical malaria in children living in an area of seasonal malaria transmission in Burkina Faso, West Africa.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Long-term clinical protection from falciparum malaria is strongly associated with IgG3 antibodies to merozoite surface protein 3.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Grand challenges in global health: community engagement in research in developing countries

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Transmission-blocking activity induced by malaria vaccine candidates Pfs25/Pvs25 is a direct and predictable function of antibody titer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Attrition in geriatric research: how important is it and how should it be dealt with?

30 September 2017

1 reference

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Valid consent for genomic epidemiology in developing countries

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

A review of human vaccine research and development: malaria

30 September 2017

1 reference

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Recruitment and retention of Latinos in a primary care-based physical activity and diet trial: The Resources for Health study

30 September 2017

1 reference

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Relationship between the entomologic inoculation rate and the force of infection for Plasmodium falciparum malaria

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Malaria: deploying a candidate vaccine (RTS,S/AS02A) for an old scourge of humankind

30 September 2017

1 reference

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Pre-erythrocytic malaria vaccines: towards greater efficacy

30 September 2017

1 reference

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Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial

30 September 2017

1 reference

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Relationships between the outcome of Plasmodium falciparum infection and the intensity of transmission in Africa.

30 September 2017

1 reference

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Merozoite surface protein 1, immune evasion, and vaccines against asexual blood stage malaria

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Prognostic value of anti-Plasmodium falciparum-specific immunoglobulin G3, cytokines, and their soluble receptors in West African patients with severe malaria

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Natural immune response to the C-terminal 19-kilodalton domain of Plasmodium falciparum merozoite surface protein 1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Attributable fraction estimates and case definitions for malaria in endemic areas

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Protection against a malaria challenge by sporozoite inoculation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

European and Developing Countries Clinical Trials Partnership (EDCTP): the path towards a true partnership

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

IgG3 antibodies to Plasmodium falciparum merozoite surface protein 2 (MSP2): increasing prevalence with age and association with clinical immunity to malaria.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

IgG1 and IgG2 antibody responses to Plasmodium falciparum exoantigens correlate inversely and positively, respectively, to the number of malaria attacks

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Antibodies in falciparum malaria: what matters most, quantity or quality?

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

28 June 2018

A vaccine for malaria.

1 reference

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First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Malaria and pregnancy: a global health perspective.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Clinical development of malaria vaccines: should earlier trials be done in malaria endemic countries?

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Antibody responses to a panel of Plasmodium falciparum malaria blood-stage antigens in relation to clinical disease outcome in Sudan.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Measurement of malaria vaccine efficacy in phase III trials: report of a WHO consultation.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Community permission for medical research in developing countries.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Global voices of science. It takes a village: medical research and ethics in Mali

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for association with protection for IgG1 and disease for IgG2.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Immunologic responses to soluble exoantigens of Plasmodium falciparum in Gabonese children exposed to continuous intense infection.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599886

Quality improvement in the developing world

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23496910

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Strengthening research partnerships for better health and sustainable development. Abstracts of the Sixth EDCTP (European and Developing Countries Clinical Trials Partnership) Forum. October 9-12, 2011. Addis Ababa, Ethiopia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23496910

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1475-2875-12-86

1 reference

Dimensions Publication ID

15 August 2017

0 references

1 reference

15 August 2017

1 reference