Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil (Q36696078)

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scientific article published on December 2006

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English	Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil	scientific article published on December 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

1 reference

Europe PubMed Central

Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

neurodegeneration

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based on heuristic

inferred from title

4

object named as

Orly Weinreb

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

Moussa B. H. Youdim

1

object named as

Moussa B H Youdim

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

author name string

Tamar Amit

2

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

Orit Bar-Am

3

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

Mara Yogev-Falach

5

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

publication date

1 December 2006

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Europe PubMed Central

PubMed publication ID

15 August 2017

Neurotoxicity Research

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Europe PubMed Central

PubMed publication ID

15 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

3-4

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

181-192

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

Is the forced swimming test a suitable model for revealing antidepressant activity?

1 reference

https://api.crossref.org/works/10.1007%2FBF03033355

21 January 2018

Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment

1 reference

https://api.crossref.org/works/10.1007%2FBF03033355

21 January 2018

MPTP: a neurotoxin relevant to the pathophysiology of Parkinson's disease. The 1985 George C. Cotzias lecture

1 reference

https://api.crossref.org/works/10.1007%2FBF03033355

21 January 2018

The occurrence of depression in Parkinson's disease. A community-based study.

1 reference

https://api.crossref.org/works/10.1007%2FBF03033355

21 January 2018

Rational design of dual-functional aptamers that inhibit the protease and helicase activities of HCV NS3.

1 reference

https://api.crossref.org/works/10.1007%2FBF03033355

21 January 2018

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

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Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

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Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

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Rasagiline, a monoamine oxidase-B inhibitor, protects NGF-differentiated PC12 cells against oxygen-glucose deprivation

1 reference

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12 December 2020

based on heuristic

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N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

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Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

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A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study

1 reference

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12 December 2020

based on heuristic

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Characterization of the effect of ganstigmine (CHF2819) on amyloid precursor protein metabolism in SH-SY5Y neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

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Prevalence and treatment of depression in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

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The establishment of a reliable cytotoxic system with SK-N-SH neuroblastoma cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

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Alzheimer's disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of MPTP-induced neurotoxicity by AGN-1133 and AGN-1135, selective inhibitors of monoamine oxidase-B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors: new roles and therapeutic alternatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

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The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

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Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA microarray-based analysis of differentially expressed genes in transgenic brains expressing NSE-controlled APPsw.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On tyramine, food, beverages and the reversible MAO inhibitor moclobemide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preclinical view of cholinesterase inhibitors in neuroprotection: do they provide more than symptomatic benefits in Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

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Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large-scale microarray studies of gene expression in multiple regions of the brain in schizophrenia and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective actions of Selegiline in inhibiting 1-methyl, 4-phenyl, pyridinium ion (MPP+)-induced apoptosis in SK-N-SH neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine metabolism and neurotransmission in primate brain in relationship to monoamine oxidase A and B inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deamination of dopamine by human brain monoamine oxidase. Specificity for the two enzyme forms in seven brain regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depression in Parkinson's disease: conceptual issues and clinical challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cholinergic hypothesis of Alzheimer's disease: a review of progress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications of combined treatment with 'Madopar' and L-deprenil in Parkinson's disease. A long-term study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multifunctional redox catalysts as selective enhancers of oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of amyloid precursor protein cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Deprenyl protection of 1-methyl-4 phenylpyridium ion (MPP+)-induced apoptosis independent of MAO-B inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death mechanisms in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase inhibitors: novel activities of old molecules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase induces the expression of the beta-amyloid precursor protein in glia and activates glial cells in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline: an anti-Parkinson drug with neuroprotective activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple Forms of Human Brain Mitochondrial Monoamine Oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational drug design of multifunctional phosphoramidate substituted nucleoside analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limited potentiation of blood pressure response to oral tyramine by brain-selective monoamine oxidase A-B inhibitor, TV-3326 in conscious rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of MAO-B inhibitors on MPP+ toxicity in Vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology and neuroprotective properties of rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 family: life-or-death switch

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic processing of Alzheimer's amyloid precursor protein in vitro and its modulation by metal ions and tacrine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurochemical and behavioral effects of the novel cholinesterase-monoamine oxidase inhibitor, ladostigil, in response to L-dopa and L-tryptophan, in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence, etiology, and treatment of depression in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective actions of selegiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of multifunctional peptides expressing both antimicrobial activity and shiga toxin neutralization activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17197368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF03033355

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

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