Physiological role and regulation of the Na+/H+ exchanger (Q36706197)

15 August 2017

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title

Physiological role and regulation of the Na+/H+ exchanger (English)

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15 August 2017

Mackenzie E Malo

1

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PubMed ID

17218973

15 August 2017

Larry Fliegel

series ordinal

2

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15 August 2017

1 November 2006

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Canadian Journal of Physiology and Pharmacology

15 August 2017

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15 August 2017

84

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15 August 2017

1081-1095

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15 August 2017

11

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Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.

15 August 2017

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Role of the cardiac Na+/H+ exchanger during ischemia and reperfusion

21 January 2018

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Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain

21 January 2018

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Protection of the ischaemic myocardium by Na+/H+ exchange inhibitors: potential mechanisms of action

21 January 2018

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Regulatory effects of G protein-coupled receptors on cardiac sarcolemmal Na+/H+ exchanger activity: signalling and significance.

21 January 2018

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Na(+)/H(+) exchange inhibitors for cardioprotective therapy: progress, problems and prospects

21 January 2018

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Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor

21 January 2018

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Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain

21 January 2018

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The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors

21 January 2018

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Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines

21 January 2018

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The positive inotropic effect of angiotensin II: role of endothelin-1 and reactive oxygen species

21 January 2018

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The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain

21 January 2018

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Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice.

21 January 2018

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Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.

21 January 2018

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Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation

21 January 2018

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Characterization of the placental brush border membrane Na+/H+ exchanger: identification of thiol-dependent transitions in apparent molecular size

21 January 2018

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Identification of the protein and cDNA of the cardiac Na+/H+ exchanger

21 January 2018

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Phosphorylation of the C-terminal domain of the Na+/H+ exchanger by Ca2+/calmodulin-dependent protein kinase II

21 January 2018

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Emerging medicinal roles for lysophospholipid signaling

21 January 2018

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Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger

21 January 2018

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Multiple carbohydrate moieties on the Na+/H+ exchanger

21 January 2018

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Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway.

21 January 2018

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G alpha 13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways

21 January 2018

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Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH.

21 January 2018

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Proton transport and cell function

21 January 2018

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Aldosterone Increases NHE-1 Expression and Induces NHE-1-Dependent Hypertrophy in Neonatal Rat Ventricular Myocytes

21 January 2018

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The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention

21 January 2018

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Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization

21 January 2018

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Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.

21 January 2018

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What makes the bioactive lipids phosphatidic acid and lysophosphatidic acid so special?

21 January 2018

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A simple method for displaying the hydropathic character of a protein

21 January 2018

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The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH.

21 January 2018

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14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange

21 January 2018

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Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger

21 January 2018

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Functional analysis of acidic amino acids in the cytosolic tail of the Na+/H+ exchanger

21 January 2018

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A novel carbonic anhydrase II binding site regulates NHE1 activity

21 January 2018

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The Na+/H+ exchanger cytoplasmic tail: structure, function, and interactions with tescalcin

21 January 2018

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A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange

21 January 2018

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Open tubular immobilized metal ion affinity chromatography combined with MALDI MS and MS/MS for identification of protein phosphorylation sites

21 January 2018

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Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury

21 January 2018

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Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1

21 January 2018

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Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1.

21 January 2018

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An overview of inhibitors of Na(+)/H(+) exchanger

21 January 2018

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Protein phosphatase regulation of Na+/H+ exchanger isoform I.

21 January 2018

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Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium

21 January 2018

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Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation

21 January 2018

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Na(+)/H(+) exchanger isoforms are differentially regulated in rat submandibular gland during acid/base disturbances in vivo.

21 January 2018

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Diversity of the mammalian sodium/proton exchanger SLC9 gene family

21 January 2018

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Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers

21 January 2018

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Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger

21 January 2018

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The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells

21 January 2018

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Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation

21 January 2018

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A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH

21 January 2018

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pHi regulatory ion transporters: an update on structure, regulation and cell function

21 January 2018

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Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition

21 January 2018

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Expression profile of genes regulated by activity of the Na-H exchanger NHE1

21 January 2018

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When 7 transmembrane receptors are not G protein-coupled receptors

21 January 2018

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Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation

21 January 2018

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Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

21 January 2018

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Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD

21 January 2018

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Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter

21 January 2018

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Angiotensin II signal transduction: Stimulation of multiple mitogen-activated protein kinase pathways.

21 January 2018

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Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion

21 January 2018

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Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion

21 January 2018

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Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger

21 January 2018

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Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.

21 January 2018

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An overview of endothelin signaling in the cardiac myocyte

21 January 2018

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Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

21 January 2018

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Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading

21 January 2018

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p160ROCK mediates RhoA activation of Na-H exchange

21 January 2018

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The ezrin protein family: membrane-cytoskeleton interactions and disease associations

21 January 2018

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The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing"

21 January 2018

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Calmodulin-binding autoinhibitory domain controls "pH-sensing" in the Na+/H+ exchanger NHE1 through sequence-specific interaction

21 January 2018

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A novel topology model of the human Na(+)/H(+) exchanger isoform 1

21 January 2018

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Two G protein-coupled receptors activate Na+/H+ exchanger isoform 1 in Chinese hamster lung fibroblasts through an ERK-dependent pathway

21 January 2018

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The Na+/H+ antiporter potentiates growth and retinoic acid-induced differentiation of P19 embryonal carcinoma cells

21 January 2018

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The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.

21 January 2018

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The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor

21 January 2018

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The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial

21 January 2018

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Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/Y06-065

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15 August 2017

1 reference

PubMed ID

17218973