Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. (Q30476292)

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English	Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.	scientific article

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9 January 2020

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice (English)

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9 January 2020

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Junichi Sadoshima

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Dorothy E Vatner

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Dorothy E Vatner

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Stephen F Vatner

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Stephen F Vatner

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Dan M Roden

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Peiyong Zhai

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Mitsutaka Yamamoto

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Jonathan Galeotti

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Jing Liu

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Malthi Masurekar

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Jill Thaisz

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Keiichi Irie

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Eric Holle

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Xianzhong Yu

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Sabina Kupershmidt

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Thomas Wagner

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Atsuko Yatani

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1 November 2005

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9 January 2020

Journal of Clinical Investigation

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3045-3056

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9 January 2020

Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A(3) adenosine receptors

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Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy

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Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block

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Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

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20 June 2018

Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes

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20 June 2018

The renin-angiotensin system in the twenty-first century

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20 June 2018

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

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20 June 2018

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20 June 2018

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20 June 2018

Tyrosine kinase activation by the angiotensin II receptor in the absence of calcium signaling

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Cytoplasmic signaling pathways that regulate cardiac hypertrophy

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20 June 2018

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

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20 June 2018

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

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20 June 2018

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

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Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.

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20 June 2018

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Heptahelical receptor signaling: beyond the G protein paradigm.

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Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro

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20 June 2018

Oncogenic src, raf, and ras stimulate a hypertrophic pattern of gene expression and increase cell size in neonatal rat ventricular myocytes.

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20 June 2018

Versatility of the angiotensin II type 1 receptor.

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20 June 2018

Angiotensin II-induced association of phospholipase Cgamma1 with the G-protein-coupled AT1 receptor

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20 June 2018

Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor

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20 June 2018

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20 June 2018

Phospholamban deficiency alters inactivation kinetics of L-type Ca2+ channels in mouse ventricular myocytes

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20 June 2018

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Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

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Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

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Domains for G-protein coupling in angiotensin II receptor type I: studies by site-directed mutagenesis

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Characterization of angiotensin II receptor subtypes in rat heart

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Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes

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Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart

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Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.

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Oligomerization of wild type and nonfunctional mutant angiotensin II type I receptors inhibits galphaq protein signaling but not ERK activation.

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Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.

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Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor

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AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs.

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26 November 2018

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26 November 2018

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26 November 2018

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ANG II type 1 receptor downregulation does not require receptor endocytosis or G protein coupling

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12 December 2020

based on heuristic

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beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation

1 reference

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12 December 2020

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Is an intracellular renin-angiotensin system involved in control of cell communication in heart?

1 reference

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12 December 2020

based on heuristic

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1 reference

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12 December 2020

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Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice

1 reference

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based on heuristic

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Identifiers

10.1172/JCI25330

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9 January 2020

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9 January 2020

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9 January 2020

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