Systemic infections and inflammation affect chronic neurodegeneration (Q36707203)

15 August 2017

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title

Systemic infections and inflammation affect chronic neurodegeneration (English)

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15 August 2017

V Hugh Perry

1

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PubMed ID

17220915

15 August 2017

Colm Cunningham

series ordinal

2

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PubMed ID

17220915

15 August 2017

Clive Holmes

series ordinal

3

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15 August 2017

15 January 2007

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Nature Reviews Immunology

15 August 2017

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15 August 2017

7

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15 August 2017

161-167

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15 August 2017

2

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Pattern recognition by TREM-2: binding of anionic ligands

15 August 2017

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Role of interleukin-1 in prion disease-associated astrocyte activation

21 January 2018

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Predictors of cognitive decline and mortality of aged people over a 10-year period.

21 January 2018

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Diabetes mellitus and the risk of dementia: The Rotterdam Study.

21 January 2018

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Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease.

21 January 2018

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Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

31 March 2020

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Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity.

31 March 2020

1 reference

31 March 2020

The inflammatory reflex

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Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain.

31 March 2020

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Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines.

31 March 2020

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Inflammatory response: pathway across the blood-brain barrier.

31 March 2020

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Macrophages and microglia in the nervous system

31 March 2020

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

31 March 2020

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Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

31 March 2020

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Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production.

31 March 2020

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Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia

31 March 2020

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Microglia: a sensor for pathological events in the CNS

31 March 2020

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Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function

31 March 2020

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Alternative activation of macrophages

31 March 2020

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Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences

31 March 2020

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Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

31 March 2020

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Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

31 March 2020

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Inflammation and Alzheimer's disease

31 March 2020

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Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.

31 March 2020

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Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

31 March 2020

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The microglial phagocytic role with specific plaque types in the Alzheimer disease brain

31 March 2020

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

31 March 2020

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Role of microglia and host prion protein in neurotoxicity of a prion protein fragment.

31 March 2020

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A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.

31 March 2020

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Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

31 March 2020

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Prolonged exposure of microglia to lipopolysaccharide modifies the intracellular signaling pathways and selectively promotes prostaglandin E2 synthesis.

31 March 2020

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Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

31 March 2020

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Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

31 March 2020

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Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease.

31 March 2020

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Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease

31 March 2020

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Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

31 March 2020

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Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.

31 March 2020

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Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis.

31 March 2020

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Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration.

31 March 2020

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Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease

31 March 2020

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Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease

31 March 2020

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Role of TNF-alpha receptors in mice intoxicated with the parkinsonian toxin MPTP.

31 March 2020

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Tumor necrosis factor-alpha receptor ablation in a chronic MPTP mouse model of Parkinson's disease

31 March 2020

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Inducible cytokine gene expression in the brain in the ME7/CV mouse model of scrapie is highly restricted, is at a strikingly low level relative to the degree of gliosis and occurs only late in disease

31 March 2020

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Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease

31 March 2020

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Transforming growth factor beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix

31 March 2020

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MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease.

31 March 2020

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Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie

31 March 2020

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Cytokine regulation of TNF-alpha mRNA and protein production by unprimed macrophages from C57Bl/6 and NZW mice

31 March 2020

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31 March 2020

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Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures

31 March 2020

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Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

31 March 2020

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TGFbeta1 regulates the inflammatory response during chronic neurodegeneration

31 March 2020

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Accelerated prion disease in the absence of interleukin-10.

31 March 2020

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Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice

31 March 2020

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Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.

31 March 2020

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Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration

31 March 2020

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

31 March 2020

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

31 March 2020

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The impact of systemic infection on the progression of neurodegenerative disease.

31 March 2020

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Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system.

31 March 2020

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Altered antigen expression of microglia in the aged rodent CNS.

31 March 2020

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Interleukin-6 in the aging brain.

31 March 2020

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Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury.

31 March 2020

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Peripheral infection and aging interact to impair hippocampal memory consolidation.

31 March 2020

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Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.

31 March 2020

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Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

31 March 2020

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Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.

31 March 2020

1 reference

Delirium episode as a sign of undetected dementia among community dwelling elderly subjects: a 2 year follow up study

31 March 2020

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Delirium superimposed on dementia: a systematic review

31 March 2020

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Association between dementia and infectious disease: evidence from a case-control study.

31 March 2020

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Inflammatory proteins in plasma and the risk of dementia: the rotterdam study.

31 March 2020

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Depression and the risk of Alzheimer disease.

31 March 2020

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Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication.

31 March 2020

1 reference

A prospective longitudinal study of apathy in Alzheimer's disease

31 March 2020

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Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study.

31 March 2020

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Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study

31 March 2020

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Apathy in patients with mild cognitive impairment and the risk of developing dementia of Alzheimer's disease: a one-year follow-up study

31 March 2020

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Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer's Disease

31 March 2020

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Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications.

31 March 2020

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Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease.

31 March 2020

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Biological basis of the behavior of sick animals

31 March 2020

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Differential induction of interleukin-1beta and tumour necrosis factor-alpha may account for specific patterns of leukocyte recruitment in the brain

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2015

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15 August 2017

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PubMed ID

17220915