Synthetic non-peptide mimetics of alpha-helices (Q36723211)

15 August 2017

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title

Synthetic non-peptide mimetics of alpha-helices (English)

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15 August 2017

Jessica M Davis

1

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PubMed ID

17264933

15 August 2017

Lun K Tsou

series ordinal

2

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PubMed ID

17264933

15 August 2017

Andrew D Hamilton

series ordinal

3

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15 August 2017

4 January 2007

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15 August 2017

Chemical Society Reviews

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15 August 2017

36

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15 August 2017

2

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15 August 2017

326-334

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Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

15 August 2017

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Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions

21 January 2018

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Helix geometry in proteins

21 January 2018

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Frequencies of amino acid strings in globular protein sequences indicate suppression of blocks of consecutive hydrophobic residues

21 January 2018

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Sequence motifs, polar interactions and conformational changes in helical membrane proteins

21 January 2018

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The design of dipeptide helical mimetics, Part I: the synthesis of 1,6-disubstituted indanes

21 January 2018

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The design of dipeptide helical mimetics: the synthesis and biological activity of trisubstituted indanes

21 January 2018

1 reference

The design of dipeptide helical mimetics: The synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes

21 January 2018

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Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

21 January 2018

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Strategies for targeting protein-protein interactions with synthetic agents.

21 January 2018

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Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction

21 January 2018

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Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

21 January 2018

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Substituted 1,4-benzodiazepine-2,5-diones as alpha-helix mimetic antagonists of the HDM2-p53 protein-protein interaction.

21 January 2018

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Design and modular parallel synthesis of a MCR derived alpha-helix mimetic protein-protein interaction inhibitor scaffold.

21 January 2018

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Design, synthesis, and in vitro biological evaluation of small molecule inhibitors of estrogen receptor alpha coactivator binding

21 January 2018

1 reference

Protein-protein interfaces: mimics and inhibitors

21 January 2018

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Protein-protein interactions and cancer: small molecules going in for the kill

21 January 2018

1 reference

Structure of the translocator domain of a bacterial autotransporter

21 January 2018

1 reference

Core structure of gp41 from the HIV envelope glycoprotein

21 January 2018

1 reference

Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion

21 January 2018

1 reference

Activation of smooth muscle myosin light chain kinase by calmodulin. Role of LYS(30) and GLY(40).

21 January 2018

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Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex

21 January 2018

1 reference

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

21 January 2018

1 reference

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

21 January 2018

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Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

21 January 2018

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A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells

21 January 2018

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Life-or-death decisions by the Bcl-2 protein family.

21 January 2018

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Double identity for proteins of the Bcl-2 family

21 January 2018

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

21 January 2018

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Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

21 January 2018

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

21 January 2018

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Tachykinins and tachykinin receptors: a growing family

21 January 2018

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Dynamic combinatorial networks in nuclear receptor-mediated transcription

21 January 2018

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Signaling to the Rho GTPases: networking with the DH domain

21 January 2018

1 reference

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

21 January 2018

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A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

21 January 2018

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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

21 January 2018

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

21 January 2018

1 reference

Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain

21 January 2018

1 reference

A Novel Strategy for Improving Ligand Selectivity in Receptor-Based Drug Design

21 January 2018

1 reference

The LxxLL motif: a multifunctional binding sequence in transcriptional regulation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1039/B608043J

1 reference

15 August 2017

1 reference

PubMed ID

17264933