Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect (Q36727282)

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scientific article published on 24 January 2008

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English	Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect	scientific article published on 24 January 2008

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scholarly article

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Europe PubMed Central

15 August 2017

Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect (English)

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Europe PubMed Central

15 August 2017

Stephen H. Hughes

6

object named as

Stephen H Hughes

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Europe PubMed Central

15 August 2017

author name string

Lu Gao

1

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Europe PubMed Central

15 August 2017

Mark Nils Hanson

2

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Europe PubMed Central

15 August 2017

Mini Balakrishnan

3

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Europe PubMed Central

15 August 2017

Paul L Boyer

4

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Europe PubMed Central

15 August 2017

Bernard P Roques

5

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Europe PubMed Central

15 August 2017

Baek Kim

7

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15 August 2017

Robert A Bambara

8

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Europe PubMed Central

15 August 2017

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publication date

24 January 2008

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15 August 2017

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10

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Journal of Biological Chemistry

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15 August 2017

283

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14

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15 August 2017

9196-9205

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15 August 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2431043/fullTextXML

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Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage

1 reference

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Mechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptases

1 reference

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Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase

1 reference

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Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency

1 reference

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YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro.

1 reference

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Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H

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Structural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switching

1 reference

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The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

1 reference

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Wild-type and YMDD mutant murine leukemia virus reverse transcriptases are resistant to 2',3'-dideoxy-3'-thiacytidine

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Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val.

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Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

1 reference

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Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase

1 reference

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

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Limiting deoxynucleoside triphosphate concentrations emphasize the processivity defect of lamivudine-resistant variants of human immunodeficiency virus type 1 reverse transcriptase

1 reference

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Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.

1 reference

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Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate

1 reference

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Strand displacement synthesis of the long terminal repeats by HIV reverse transcriptase

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The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

1 reference

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Physiological concentrations of purines and pyrimidines

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Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

1 reference

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High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

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Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1.

1 reference

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Genetic recombination of human immunodeficiency virus

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Site-specific mutagenesis of AIDS virus reverse transcriptase

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Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination

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First large scale chemical synthesis of the 72 amino acid HIV-1 nucleocapsid protein NCp7 in an active form.

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Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function

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On the processive mechanism of Escherichia coli DNA polymerase I. Quantitative assessment of processivity

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Development of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelity

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Mutations at position 184 of human immunodeficiency virus type-1 reverse transcriptase affect virus titer and viral DNA synthesis

1 reference

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The kissing hairpin sequence promotes recombination within the HIV-I 5' leader region.

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Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures

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Reduced dNTP interaction of human immunodeficiency virus type 1 reverse transcriptase promotes strand transfer

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1 reference

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Identifiers

10.1074/JBC.M710148200

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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