The biology and therapeutic potential of interleukin 27. (Q36733744)

16 August 2017

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title

The biology and therapeutic potential of interleukin 27. (English)

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16 August 2017

2

Nico Ghilardi

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author name string

Marcel Batten

series ordinal

1

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16 August 2017

10 February 2007

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Journal of Molecular Medicine

16 August 2017

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16 August 2017

85

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16 August 2017

7

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16 August 2017

661-672

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https://scigraph.springernature.com/pub.10.1007/s00109-007-0164-7

16 August 2017

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cites work

EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation.

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Differential effects of IL-27 on human B cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Induction of IgG2a class switching in B cells by IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

A role for IL-27 in early regulation of Th1 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

WSX-1: a key role in induction of chronic intestinal nematode infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

IL-27 limits IL-2 production during Th1 differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Antiangiogenic and antitumor activities of IL-27.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-007-0164-7

Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.

21 January 2018

1 reference

12 December 2020

IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

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12 December 2020

Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations.

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12 December 2020

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

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12 December 2020

Antigen-driven effector CD8 T cell function regulated by T-bet

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12 December 2020

T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis

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12 December 2020

Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

1 reference

12 December 2020

Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice

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12 December 2020

Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1

1 reference

12 December 2020

IL-12 induces T helper 1-directed antitumor response

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12 December 2020

No inhibition of IL-27 signaling by soluble gp130.

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12 December 2020

Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology

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12 December 2020

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

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12 December 2020

Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

1 reference

12 December 2020

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

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12 December 2020

STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis

1 reference

12 December 2020

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

1 reference

12 December 2020

A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

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12 December 2020

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice

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12 December 2020

Interleukin-6 is required for parasite specific response and host resistance to Trypanosoma cruzi.

1 reference

12 December 2020

The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

1 reference

12 December 2020

Jaks and STATs: biological implications

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12 December 2020

The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis

1 reference

12 December 2020

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

1 reference

12 December 2020

Molecular mechanisms underlying IFN-gamma-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12

1 reference

12 December 2020

The dichotomous role of IL-2: tolerance versus immunity.

1 reference

12 December 2020

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

1 reference

12 December 2020

Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.

1 reference

12 December 2020

Interleukin-17 family members and inflammation

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12 December 2020

IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice

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12 December 2020

Expression of IL-27 in human Th1-associated granulomatous diseases

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12 December 2020

Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells

1 reference

12 December 2020

Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major

1 reference

12 December 2020

Acquiring signalling specificity from the cytokine receptor gp130.

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12 December 2020

Targeting IL-23 in autoimmunity.

1 reference

12 December 2020

IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages.

1 reference

12 December 2020

Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection

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12 December 2020

Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma.

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12 December 2020

Adjuvant activities of novel cytokines, interleukin-23 (IL-23) and IL-27, for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice.

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12 December 2020

The T-box transcription factor T-bet in immunity and autoimmunity

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12 December 2020

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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12 December 2020

IL-12: a promising adjuvant for cancer vaccination

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12 December 2020

Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals.

1 reference

12 December 2020

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

1 reference

12 December 2020

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice

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12 December 2020

A protective role for IL-6 during early infection with Toxoplasma gondii.

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12 December 2020

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

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12 December 2020

A function for interleukin 2 in Foxp3-expressing regulatory T cells

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12 December 2020

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

1 reference

12 December 2020

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

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12 December 2020

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

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12 December 2020

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

1 reference

12 December 2020

WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production

1 reference

12 December 2020

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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12 December 2020

Cloning and characterization of a novel class I cytokine receptor

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12 December 2020

Pathological role of IL-6 in the experimental allergic bronchial asthma in mice

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12 December 2020

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

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12 December 2020

Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1)

1 reference

12 December 2020

The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.

1 reference

12 December 2020

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

1 reference

12 December 2020

Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice

1 reference

12 December 2020

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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12 December 2020

Potent antitumor activity of interleukin-27.

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12 December 2020

Stimulation through intercellular adhesion molecule-1 provides a second signal for T cell activation

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12 December 2020

IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.

1 reference

12 December 2020

Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epithelium

1 reference

12 December 2020

10.1007/S00109-007-0164-7

Identifiers

DOI

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16 August 2017

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PubMed ID

17294231